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Kyutacarは九州工業大学で生産された研究成果を オープンアクセスで提供する機関リポジトリシステムです。 Kyutacar is open-access repository of research by members of the Kyushu Institute of Technology.
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
Frontier Research Academy for Young Researchers, Kyushu Institute of Technology
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
抄録
Phosphate groups on materials surfaces are known to contribute to apatite formation upon exposure of the materials in simulated body fluid and improved affinity of the materials for osteoblast-like cells. Typically, polymers containing phosphate groups are organic matrices consisting of apatite–polymer composites prepared by biomimetic process using simulated body fluid. Ca2+ incorporation into the polymer accelerates apatite formation in simulated body fluid owing because of increase in the supersaturation degree, with respect to apatite in simulated body fluid, owing to Ca2+ release from the polymer. However, the effects of phosphate content on the Ca2+ release and apatite-forming abilities of copolymers in simulated body fluid are rather elusive. In this study, a phosphate-containing copolymer prepared from vinylphosphonic acid, 2-hydroxyethyl methacrylate, and triethylene glycol dimethacrylate was examined. The release of Ca2+ in Tris-NaCl buffer and simulated body fluid increased as the additive amount of vinylphosphonic acid increased. However, apatite formation was suppressed as the phosphate groups content increased despite the enhanced release of Ca2+ from the polymer. This phenomenon was reflected by changes in the surface zeta potential. Thus, it was concluded that the apatite-forming ability of vinylphosphonic acid-2-hydroxyethyl methacrylate-triethylene glycol dimethacrylate copolymer treated with CaCl2 solution was governed by surface state rather than Ca2+ release in simulated body fluid.
雑誌名
Journal of Materials Science: Materials in Medicine
巻
27
号
10
ページ
152
発行年
2016-09-01
出版者
Springer US
ISSN
0957-4530
1573-4838
書誌レコードID
AA10761712
DOI
https://doi.org/10.1007/s10856-016-5761-y
権利
Springer Science+Business Media New York 2016
The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-016-5761-y
Apatite-forming ability of vinylphosphonic acid-based copolymer in simulated body fluid: effects of phosphate group content
JMSM-D-16-00098_R1.pdf
(685.61KB)
