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Efficient near infrared fluorescence detection of elastase enzyme using peptide-bound unsymmetrical squaraine dye
http://hdl.handle.net/10228/00007299
http://hdl.handle.net/10228/00007299063b5979-d57a-4400-a1bc-9ef53b4bf7f6
名前 / ファイル | ライセンス | アクション |
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BMCL27_4024.pdf (427.0 kB)
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Item type | 学術雑誌論文 = Journal Article(1) | |||||||||
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公開日 | 2019-07-22 | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
タイトル | ||||||||||
タイトル | Efficient near infrared fluorescence detection of elastase enzyme using peptide-bound unsymmetrical squaraine dye | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
著者 |
Saikiran, Maryala
× Saikiran, Maryala× Sato, Daisuke× パンディ, シャム スディル
WEKO
6311
× 早瀬, 修二× 加藤, 珠樹 |
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Extended wavelength analyte-responsive fluorescent probes are highly desired for the imaging applications owing to their deep tissue penetration, and minimum interference from autofluorescence by biomolecules. Near infra-red (NIR) sensitive and self-quenching fluorescent probe based on the dye-peptide conjugate (SQ 1 PC) was designed and synthesized by facile and efficient one-pot synthetic route for the detection of Elastase activity. In the phosphate buffer solution, there was an efficient quenching of fluorescence of SQ 1 PC (86%) assisted by pronounced dye-dye interaction due to H-aggregate formation. Efficient and fast recovery of this quenched fluorescence of SQ 1 PC (> 50% in 30 s) was observed on hydrolysis of this peptide-dye conjugate by elastase enzyme. Presently designed NIR sensitive self-quenching substrate offers the potential application for the detection of diseases related to proteases by efficient and fast detection of their activities. | |||||||||
書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 27, 号 17, p. 4024-4029, 発行日 2017-07-22 |
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出版社 | ||||||||||
出版者 | Elsevier | |||||||||
DOI | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.1016/j.bmcl.2017.07.057 | |||||||||
NCID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA1079577X | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0960-894X | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1464-3405 | |||||||||
著作権関連情報 | ||||||||||
権利情報 | Copyright (c) 2017 Elsevier Ltd. | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Far-red squaraine dye | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Aggregation | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Fluorescent peptide | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Self-quenching | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Dye-peptide conjugate | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Elastase detection | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Bio imaging | |||||||||
出版タイプ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
査読の有無 | ||||||||||
値 | yes | |||||||||
研究者情報 | ||||||||||
https://hyokadb02.jimu.kyutech.ac.jp/html/332_ja.html | ||||||||||
論文ID(連携) | ||||||||||
10309948 | ||||||||||
連携ID | ||||||||||
6623 | ||||||||||
資料タイプ | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Journal Article | |||||||||
著者所属 | ||||||||||
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology | ||||||||||
著者所属 | ||||||||||
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology | ||||||||||
著者所属 | ||||||||||
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology | ||||||||||
著者所属 | ||||||||||
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology | ||||||||||
著者所属 | ||||||||||
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology | ||||||||||
情報源 | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1016/j.bmcl.2017.07.057 | |||||||||
関連名称 | https://doi.org/10.1016/j.bmcl.2017.07.057 |