WEKO3
アイテム
{"_buckets": {"deposit": "b5d7429e-0ec8-4889-85e1-a8e80d1c1e01"}, "_deposit": {"created_by": 3, "id": "6420", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "6420"}, "status": "published"}, "_oai": {"id": "oai:kyutech.repo.nii.ac.jp:00006420", "sets": ["9"]}, "author_link": ["26904", "6749", "26905", "26903", "5963", "26902", "26900"], "item_21_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-02-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "668-10", "bibliographicPageStart": "668-1", "bibliographicVolumeNumber": "25", "bibliographic_titles": [{"bibliographic_title": "Molecules"}]}]}, "item_21_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation. However, G4 ligands recognizing G-quadruplex were generally investigated within a dilute condition, which might be interfered with under a cellular crowding environment. Here, we designed and synthesized several new cyclic naphthalene diimide (cNDI) derivatives, and investigated their interaction with G-quadruplex under molecular crowding condition (40% v/v polyethylene glycol (PEG)200) to mimic the cellular condition. The results indicated that, under molecular crowding conditions, cNDI derivatives were still able to recognize and stabilize G-quadruplex structures based on circular dichroism measurement. The binding affinities were slightly decreased but still comparatively high upon determination by isothermal titration calorimetry and UV-vis absorbance spectroscopy. More interestingly, cNDI derivatives were observed with preference to induce a telomere sequence to form a hybrid G-quadruplex under cation-deficient molecular crowding conditions", "subitem_description_type": "Abstract"}]}, "item_21_description_60": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_21_link_62": {"attribute_name": "研究者情報", "attribute_value_mlt": [{"subitem_link_text": "https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html", "subitem_link_url": "https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html"}]}, "item_21_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_21_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3390/molecules25030668", "subitem_relation_type_select": "DOI"}}]}, "item_21_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2020 by the authors. Licensee MDPI, Basel, Switzerland. Creative Commons Attribution (CC BY) license. http://creativecommons.org/licenses/by/4.0/"}]}, "item_21_select_59": {"attribute_name": "査読の有無", "attribute_value_mlt": [{"subitem_select_item": "yes"}]}, "item_21_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1420-3049", "subitem_source_identifier_type": "ISSN"}]}, "item_21_text_36": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Kyushu Institute of Technology"}, {"subitem_text_value": "Kyushu Institute of Technology"}, {"subitem_text_value": "Kyushu Institute of Technology"}, {"subitem_text_value": "Kyushu Institute of Technology"}, {"subitem_text_value": "Kyushu Institute of Technology"}, {"subitem_text_value": "Kyushu Institute of Technology"}, {"subitem_text_value": "Kyushu Institute of Technology"}]}, "item_21_text_63": {"attribute_name": "連携ID", "attribute_value_mlt": [{"subitem_text_value": "8132"}]}, "item_21_version_type_58": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zou, Tingting"}], "nameIdentifiers": [{"nameIdentifier": "26900", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Sato, Shinobu", "creatorNameLang": "en"}, {"creatorName": "佐藤, しのぶ", "creatorNameLang": "ja"}, {"creatorName": "サトウ, シノブ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Sato", "familyNameLang": "en"}, {"familyName": "佐藤", "familyNameLang": "ja"}, {"familyName": "サトウ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Shinobu", "givenNameLang": "en"}, {"givenName": "しのぶ", "givenNameLang": "ja"}, {"givenName": "シノブ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5963", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80510677", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000080510677"}, {"nameIdentifier": "7501769466", "nameIdentifierScheme": "Scopus著者ID", "nameIdentifierURI": "https://www.scopus.com/authid/detail.uri?authorId=7501769466"}, {"nameIdentifier": "395", "nameIdentifierScheme": "九工大研究者情報", "nameIdentifierURI": "https://hyokadb02.jimu.kyutech.ac.jp/html/395_ja.html"}]}, {"creatorNames": [{"creatorName": "Yasukawa, Rui"}], "nameIdentifiers": [{"nameIdentifier": "26902", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeuchi, Ryusuke"}], "nameIdentifiers": [{"nameIdentifier": "26903", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozaki, Shunsuke"}], "nameIdentifiers": [{"nameIdentifier": "26904", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujii, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "26905", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Takenaka, Shigeori", "creatorNameLang": "en"}, {"creatorName": "竹中, 繁織", "creatorNameLang": "ja"}, {"creatorName": "タケナカ, シゲオリ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Takenaka", "familyNameLang": "en"}, {"familyName": "竹中", "familyNameLang": "ja"}, {"familyName": "タケナカ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Shigeori", "givenNameLang": "en"}, {"givenName": "繁織", "givenNameLang": "ja"}, {"givenName": "シゲオリ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "6749", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60188208", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000060188208"}, {"nameIdentifier": "7202789037", "nameIdentifierScheme": "Scopus著者ID", "nameIdentifierURI": "https://www.scopus.com/authid/detail.uri?authorId=7202789037"}, {"nameIdentifier": "97", "nameIdentifierScheme": "九工大研究者情報", "nameIdentifierURI": "https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "molecules25030668.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "molecules25030668.pdf", "url": "https://kyutech.repo.nii.ac.jp/record/6420/files/molecules25030668.pdf"}, "version_id": "30431d04-8e0f-4f63-8e5b-a19be2595eea"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "cyclic naphthalene diimide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "G-quadruplex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dilute condition", "subitem_subject_scheme": "Other"}, {"subitem_subject": "molecular crowding condition", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition"}]}, "item_type_id": "21", "owner": "3", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10228/00007630", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-02-20"}, "publish_date": "2020-02-20", "publish_status": "0", "recid": "6420", "relation": {}, "relation_version_is_last": true, "title": ["The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition"], "weko_shared_id": 3}
The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition
http://hdl.handle.net/10228/00007630
http://hdl.handle.net/10228/0000763070922aca-2bf1-469b-b305-ecc947c5ab50
名前 / ファイル | ライセンス | アクション |
---|---|---|
molecules25030668.pdf (1.7 MB)
|
|
Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2020-02-20 | |||||||||||||||||
資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | journal article | |||||||||||||||||
タイトル | ||||||||||||||||||
タイトル | The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
著者 |
Zou, Tingting
× Zou, Tingting× 佐藤, しのぶ
WEKO
5963
× Yasukawa, Rui× Takeuchi, Ryusuke× Ozaki, Shunsuke× Fujii, Satoshi× 竹中, 繁織
WEKO
6749
|
|||||||||||||||||
抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation. However, G4 ligands recognizing G-quadruplex were generally investigated within a dilute condition, which might be interfered with under a cellular crowding environment. Here, we designed and synthesized several new cyclic naphthalene diimide (cNDI) derivatives, and investigated their interaction with G-quadruplex under molecular crowding condition (40% v/v polyethylene glycol (PEG)200) to mimic the cellular condition. The results indicated that, under molecular crowding conditions, cNDI derivatives were still able to recognize and stabilize G-quadruplex structures based on circular dichroism measurement. The binding affinities were slightly decreased but still comparatively high upon determination by isothermal titration calorimetry and UV-vis absorbance spectroscopy. More interestingly, cNDI derivatives were observed with preference to induce a telomere sequence to form a hybrid G-quadruplex under cation-deficient molecular crowding conditions | |||||||||||||||||
書誌情報 |
Molecules 巻 25, 号 3, p. 668-1-668-10, 発行日 2020-02-04 |
|||||||||||||||||
出版社 | ||||||||||||||||||
出版者 | MDPI | |||||||||||||||||
DOI | ||||||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | https://doi.org/10.3390/molecules25030668 | |||||||||||||||||
ISSN | ||||||||||||||||||
収録物識別子タイプ | ISSN | |||||||||||||||||
収録物識別子 | 1420-3049 | |||||||||||||||||
著作権関連情報 | ||||||||||||||||||
権利情報 | Copyright (c) 2020 by the authors. Licensee MDPI, Basel, Switzerland. Creative Commons Attribution (CC BY) license. http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | cyclic naphthalene diimide | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | G-quadruplex | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | dilute condition | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | molecular crowding condition | |||||||||||||||||
出版タイプ | ||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
査読の有無 | ||||||||||||||||||
値 | yes | |||||||||||||||||
研究者情報 | ||||||||||||||||||
https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html | ||||||||||||||||||
連携ID | ||||||||||||||||||
8132 | ||||||||||||||||||
資料タイプ | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | Journal Article | |||||||||||||||||
著者所属 | ||||||||||||||||||
Kyushu Institute of Technology | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Kyushu Institute of Technology | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Kyushu Institute of Technology | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Kyushu Institute of Technology | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Kyushu Institute of Technology | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Kyushu Institute of Technology | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Kyushu Institute of Technology |