WEKO3
アイテム
{"_buckets": {"deposit": "414e59d0-6844-4b8a-84dc-bc53a9ce018b"}, "_deposit": {"created_by": 3, "id": "6107", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "6107"}, "status": "published"}, "_oai": {"id": "oai:kyutech.repo.nii.ac.jp:00006107", "sets": ["24"]}, "author_link": ["6749", "25112", "25114", "5963"], "item_21_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-11-15", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "335", "bibliographicPageStart": "329", "bibliographicVolumeNumber": "27", "bibliographic_titles": [{"bibliographic_title": "Bioorganic \u0026 Medicinal Chemistry Letters"}]}]}, "item_21_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To identify an effective ligand that binds to a G-quadruplex structure but not a double-stranded DNA (dsDNA), a set of biophysical and biochemical experiments were carried out using newly synthesized cyclic ferrocenylnaphthalene diimide (cFNDI, 1) or the non-cyclic derivative (2) with various structures of G-quadruplex DNAs and dsDNA. Compound 1 bound strongly to G-quadruplexes DNAs (106 M−1 order) with diminished binding to dsDNA (104 M−1 order) in 100 mM AcOH-AcOK buffer (pH 5.5) containing 100 mM KCl. Interestingly, 1 showed an approximately 50-fold higher selectivity to mixed hybrid-type telomeric G-quadruplex DNA (K = 3.4 × 106 M−1 and a 2:1 stoichiometry) than dsDNA (K = 7.5 × 104 M−1) did. Furthermore, 1 showed higher thermal stability to G-quadruplex DNAs than it did to dsDNA with a preference for c-kit and c-myc G-quadruplex DNAs over telomeric and thrombin binding aptamers. Additionally, 1 exhibited telomerase inhibitory activity with a half-maximal inhibitory concentration (IC50) of 0.4 μM. Compound 2 showed a preference for G-quadruplex; however, the binding affinity magnitude and preference were improved in 1 because the former had a cyclic structure.", "subitem_description_type": "Abstract"}]}, "item_21_description_60": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_21_link_62": {"attribute_name": "研究者情報", "attribute_value_mlt": [{"subitem_link_text": "https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html", "subitem_link_url": "https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html"}]}, "item_21_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_21_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bmcl.2016.11.037", "subitem_relation_type_select": "DOI"}}]}, "item_21_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2016 Elsevier Ltd."}]}, "item_21_select_59": {"attribute_name": "査読の有無", "attribute_value_mlt": [{"subitem_select_item": "yes"}]}, "item_21_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0960-894X", "subitem_source_identifier_type": "ISSN"}]}, "item_21_subject_16": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "579", "subitem_subject_scheme": "NDC"}]}, "item_21_text_36": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"}, {"subitem_text_value": "Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Center for Bio-microsensing Technology, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"}, {"subitem_text_value": "Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"}, {"subitem_text_value": "Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Center for Bio-microsensing Technology, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"}]}, "item_21_text_63": {"attribute_name": "連携ID", "attribute_value_mlt": [{"subitem_text_value": "7831"}]}, "item_21_version_type_58": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Islam, Md. Monirul"}], "nameIdentifiers": [{"nameIdentifier": "25112", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Sato, Shinobu", "creatorNameLang": "en"}, {"creatorName": "佐藤, しのぶ", "creatorNameLang": "ja"}, {"creatorName": "サトウ, シノブ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Sato", "familyNameLang": "en"}, {"familyName": "佐藤", "familyNameLang": "ja"}, {"familyName": "サトウ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Shinobu", "givenNameLang": "en"}, {"givenName": "しのぶ", "givenNameLang": "ja"}, {"givenName": "シノブ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5963", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80510677", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000080510677"}, {"nameIdentifier": "7501769466", "nameIdentifierScheme": "Scopus著者ID", "nameIdentifierURI": "https://www.scopus.com/authid/detail.uri?authorId=7501769466"}, {"nameIdentifier": "395", "nameIdentifierScheme": "九工大研究者情報", "nameIdentifierURI": "https://hyokadb02.jimu.kyutech.ac.jp/html/395_ja.html"}]}, {"creatorNames": [{"creatorName": "Shinozaki, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "25114", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Takenaka, Shigeori", "creatorNameLang": "en"}, {"creatorName": "竹中, 繁織", "creatorNameLang": "ja"}, {"creatorName": "タケナカ, シゲオリ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Takenaka", "familyNameLang": "en"}, {"familyName": "竹中", "familyNameLang": "ja"}, {"familyName": "タケナカ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Shigeori", "givenNameLang": "en"}, {"givenName": "繁織", "givenNameLang": "ja"}, {"givenName": "シゲオリ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "6749", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60188208", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000060188208"}, {"nameIdentifier": "7202789037", "nameIdentifierScheme": "Scopus著者ID", "nameIdentifierURI": "https://www.scopus.com/authid/detail.uri?authorId=7202789037"}, {"nameIdentifier": "97", "nameIdentifierScheme": "九工大研究者情報", "nameIdentifierURI": "https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "j.bmcl.2016.11.037.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "j.bmcl.2016.11.037.pdf", "url": "https://kyutech.repo.nii.ac.jp/record/6107/files/j.bmcl.2016.11.037.pdf"}, "version_id": "2186fe9c-1da2-4d1e-a6ff-29098ca197ae"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cyclic ferrocenylnaphthalene diimide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tetraplex DNA binder", "subitem_subject_scheme": "Other"}, {"subitem_subject": "G-quadruplex DNA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Human telomere DNA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Promotor region", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Thrombin binding aptamer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Double stranded DNA", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand"}]}, "item_type_id": "21", "owner": "3", "path": ["24"], "permalink_uri": "http://hdl.handle.net/10228/00007317", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-08-19"}, "publish_date": "2019-08-19", "publish_status": "0", "recid": "6107", "relation": {}, "relation_version_is_last": true, "title": ["Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand"], "weko_shared_id": 3}
Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand
http://hdl.handle.net/10228/00007317
http://hdl.handle.net/10228/00007317642e7461-d2a3-4c3b-9f7d-a2440394d31a
名前 / ファイル | ライセンス | アクション |
---|---|---|
j.bmcl.2016.11.037.pdf (1.5 MB)
|
|
Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2019-08-19 | |||||||||||||||||
資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | journal article | |||||||||||||||||
タイトル | ||||||||||||||||||
タイトル | Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
著者 |
Islam, Md. Monirul
× Islam, Md. Monirul× 佐藤, しのぶ
WEKO
5963
× Shinozaki, Shingo× 竹中, 繁織
WEKO
6749
|
|||||||||||||||||
抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | To identify an effective ligand that binds to a G-quadruplex structure but not a double-stranded DNA (dsDNA), a set of biophysical and biochemical experiments were carried out using newly synthesized cyclic ferrocenylnaphthalene diimide (cFNDI, 1) or the non-cyclic derivative (2) with various structures of G-quadruplex DNAs and dsDNA. Compound 1 bound strongly to G-quadruplexes DNAs (106 M−1 order) with diminished binding to dsDNA (104 M−1 order) in 100 mM AcOH-AcOK buffer (pH 5.5) containing 100 mM KCl. Interestingly, 1 showed an approximately 50-fold higher selectivity to mixed hybrid-type telomeric G-quadruplex DNA (K = 3.4 × 106 M−1 and a 2:1 stoichiometry) than dsDNA (K = 7.5 × 104 M−1) did. Furthermore, 1 showed higher thermal stability to G-quadruplex DNAs than it did to dsDNA with a preference for c-kit and c-myc G-quadruplex DNAs over telomeric and thrombin binding aptamers. Additionally, 1 exhibited telomerase inhibitory activity with a half-maximal inhibitory concentration (IC50) of 0.4 μM. Compound 2 showed a preference for G-quadruplex; however, the binding affinity magnitude and preference were improved in 1 because the former had a cyclic structure. | |||||||||||||||||
書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 27, 号 2, p. 329-335, 発行日 2016-11-15 |
|||||||||||||||||
出版社 | ||||||||||||||||||
出版者 | Elsevier | |||||||||||||||||
DOI | ||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | https://doi.org/10.1016/j.bmcl.2016.11.037 | |||||||||||||||||
日本十進分類法 | ||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||
主題 | 579 | |||||||||||||||||
ISSN | ||||||||||||||||||
収録物識別子タイプ | ISSN | |||||||||||||||||
収録物識別子 | 0960-894X | |||||||||||||||||
著作権関連情報 | ||||||||||||||||||
権利情報 | Copyright (c) 2016 Elsevier Ltd. | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Cyclic ferrocenylnaphthalene diimide | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Tetraplex DNA binder | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | G-quadruplex DNA | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Human telomere DNA | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Promotor region | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Thrombin binding aptamer | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Double stranded DNA | |||||||||||||||||
出版タイプ | ||||||||||||||||||
出版タイプ | AM | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
査読の有無 | ||||||||||||||||||
値 | yes | |||||||||||||||||
研究者情報 | ||||||||||||||||||
https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html | ||||||||||||||||||
連携ID | ||||||||||||||||||
7831 | ||||||||||||||||||
資料タイプ | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | Journal Article | |||||||||||||||||
著者所属 | ||||||||||||||||||
Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Center for Bio-microsensing Technology, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan | ||||||||||||||||||
著者所属 | ||||||||||||||||||
Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Center for Bio-microsensing Technology, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan |