Kyushu Institute of Technology Academic Repository
Kyutacarは九州工業大学で生産された研究成果を オープンアクセスで提供する機関リポジトリシステムです。 Kyutacar is open-access repository of research by members of the Kyushu Institute of Technology.
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4, Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4, Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan
Graduate School of Biomedical Engineering, Tohoku University, 6-6-12-208, Aramaki, Aoba, Aoba-ku, Sendai 980-8579, Japan
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
抄録
Nanocomposites of magnetite (Fe3O4) and reduced graphene oxide (rGO) generate heat under an alternating magnetic field and therefore have potential applications as thermoseeds for cancer hyperthermia treatment. However, the properties of such nanocomposites as biomaterials have not been sufficiently well characterized. In this study, the osteoconductivity of Fe3O4-rGO nanocomposites of various compositions was evaluated in vitro in terms of their apatite-forming ability in simulated body fluid (SBF). Furthermore, the heat generation of the nanocomposites was measured under an alternating magnetic field. The apatite-forming ability in SBF improved as the Fe3O4 content in the nanocomposite was increased. As the Fe3O4 content was increased, the nanocomposite not only rapidly raised the surrounding temperature to approximately 100°C, but the specific absorption rate also increased. We assumed that the ionic interaction between the Fe3O4 and rGO was enhanced and that Brown relaxation was suppressed as the proportion of rGO in the nanocomposite was increased. Consequently, a high content of Fe3O4 in the nanocomposite was effective for improving both the osteoconductivity and heat generation characteristics for hyperthermia applications.
雑誌名
Materials Science and Engineering: C
巻
99
ページ
68 - 72
発行年
2019-01-22
出版者
Elsevier
ISSN
0928-4931
書誌レコードID
AA11537849
DOI
https://doi.org/10.1016/j.msec.2019.01.091
権利
Copyright (c) 2019 Elsevier B.V. All rights reserved.
In vitro apatite mineralization and heat generation of magnetite-reduced graphene oxide nanocomposites for hyperthermia treatment
j.msec.2019.01.091.pdf
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