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DNA Concentration Regulator That can be Driven for a Long Time DNA concentration regulator that can be driven for a long time 30435664 Nakakuki, Takashi 中茎, 隆 ナカクキ, タカシ Murayama, Keiji Asanuma, Hiroyuki Copyright (c) Ohmsha, Ltd. and Springer Japan KK, part of Springer Nature 2022. This is a post-peer-review, pre-copyedit version of an article published in New Generation Computing. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00354-022-00173-3 Dynamic DNA nanotechnology Strand displacement reaction Concentration regulator Renewable A molecular robot is an autonomous micro/nano machine that mounts a molecular controller connecting the sensor and actuator systems. A major control problem of a molecular robot is to maintain the actuator operation at the desired level. This requires a regulator that adjusts the concentration of a specific DNA strand of a system to the desired level to be appropriately implemented on a chemical reaction system made of molecular interactions among DNA strands. However, although there are several research results on DNA concentration regulators, there is a major problem: the regulators normally work only within a limited period because of the finiteness problem of gate and fuel strands. The operating time of the controller is an important control performance index and is a prerequisite for its practical applications. In this study, the design of a renewable DNA concentration regulator simplified to an experimentally feasible level is proposed, inspired by the previously reported azobenzene-based photo-reaction method used for a renewable PID controller. It is shown that the methodology that timely switches the operation between "regulator mode" and "concentration recovery mode" by light irradiation can serve as a solution for the long-time operation of the DNA concentration regulator. Springer 2022-05-10 eng journal article AM http://hdl.handle.net/10228/0002000024 https://kyutech.repo.nii.ac.jp/records/2000024 https://doi.org/10.1007/s00354-022-00173-3 AA10468773 1882-7055 0288-3635 New Generation Computing 40 2 681 702 https://kyutech.repo.nii.ac.jp/record/2000024/files/s00354-022-00173-3.pdf application/pdf 2.5 MB 2023-08-02