@article{oai:kyutech.repo.nii.ac.jp:00000135,
 author = {Yamada, Hiroshi and 山田, 宏 and Takemasa, Tohru and Yamaguchi, Takami},
 issue = {11},
 journal = {Journal of Biomechanics},
 month = {Nov},
 note = {We studied stress fiber orientation under a wide range of uniaxial cyclic deformations. Wedevised and validated a hypothesis consisting of two parts, as follows: (1) a stress fiber aligns toavoid a mechanical stimulus in the fiber direction under cyclic deformation. This means that, amongall allowable directions, a stress fiber aligns in the direction which minimizes the stimulus, i.e., thesummation of the changes in length of the stress fiber over one stretch cycle; and (2) there is a limitin the sensitivity of the cellular response to the mechanical stimulus. Due to this sensing limit, theorientation angle in stress fibers is distributed around the angle corresponding to the minimumstimulus. To validate this hypothesis, we approximated an anisotropic deformation of the membraneon which cells were to be cultured. We then obtained the relationships between the stretch range andthe fiber angle in the undeformed state which minimize the mechanical stimuli, assuming that themembrane on which stress fibers and cells adhered was homogeneous and incompressible.Numerical simulation results showed that the proposed hypothesis described our previousexperimental results well and was consistent with the experimental results in the literature. Thesimulation results, taking account of the second part of the hypothesis with a small value for thelimit in sensitivity to the mechanical stimulus, could explain why cell orientation is distributed sowidely with cyclic stretch ranges of less than 10%. The proposed hypothesis can be applied tovarious types of deformation because the mechanical stimulus is always sensed and accumulatesunder cyclic deformation without the necessity of a reference state to measure the stimulus.},
 pages = {1501--1505},
 title = {Theoretical study of intracellular stress fiber orientation under cyclic deformation},
 volume = {33},
 year = {2000},
 yomi = {ヤマダ, ヒロシ}
}