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Potential of TAK-593 Ophthalmic Emulsion for the Treatment of Age-Related Macular Degeneration
http://hdl.handle.net/10228/0002000048
http://hdl.handle.net/10228/00020000483594bc63-8228-45fc-b374-09d2dd1a508f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46_b23-00066.pdf (1.9 MB)
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| Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2023-08-09 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Potential of TAK-593 Ophthalmic Emulsion for the Treatment of Age-Related Macular Degeneration | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 著者 |
Mori, Yasuhiro
× Mori, Yasuhiro
× Yamamoto, Akifumi
× Nakagawa, Ayumi
× 引間, 知広
WEKO
18296
× Isowaki, Akiharu
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Intravitreal injection therapy of anti-vascular endothelial growth factor (VEGF) antibody or steroids is the mainstream for patients with age-related macular degeneration (AMD). However, since intravitreal injection is invasive administration, side effects such as endophthalmitis are major problems. In this study, we selected eye drops as a non-invasive treatment method, and aimed to develop eye drops that can deliver TAK-593 (VEGF receptor tyrosine kinase inhibitor) to the posterior segment of the eye. Since TAK-593 is a poorly water-soluble drug, the TAK-593 emulsion was formulated. The solubility of TAK-593 in various oils was measured, and the oil used for the emulsion was selected. Furthermore, viscosity enhancers were added to the emulsion in order to improve the drug delivery into the eye. As viscosity enhancer, xanthan gum was selected based on the properties and the viscosity of the emulsion. The delivery of TAK-593 to the posterior eye was increased by the formulation concentration and the addition of viscosity enhancers. In the laser-induced choroidal neovascularization model, TAK-593 emulsion eye drops showed the same angiogenesis-suppression efficacy as anti-VEGF antibody intravitreal injection. From these results, it was revealed that TAK-593 with an effective drug concentration can be delivered to the posterior eye by non-invasive eye drop administration. | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 46, 号 7, p. 921-928, 発行日 2023-07-01 |
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| 出版社 | ||||||||||||||||||||
| 出版者 | 日本薬学会 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1248/bpb.b23-00066 | |||||||||||||||||||
| NCID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA10885497 | |||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 0918-6158 | |||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 1347-5215 | |||||||||||||||||||
| 著作権関連情報 | ||||||||||||||||||||
| 権利情報 | Copyright (c) 2023 The Pharmaceutical Society of Japan | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | eye drop | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | emulsion | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | TAK-593 | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | xanthan gum | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | posterior segment | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 査読の有無 | ||||||||||||||||||||
| 値 | yes | |||||||||||||||||||
| 研究者情報 | ||||||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/285_ja.html | |||||||||||||||||||
