| アイテムタイプ |
学術雑誌論文 = Journal Article(1) |
| 公開日 |
2024-02-01 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| タイトル |
|
|
タイトル |
DNA Reaction System That Acquires Classical Conditioning |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 著者 |
中茎, 隆
Toyonari, Masato
Aso, Kaori
Murayama, Keiji
Asanuma, Hiroyuki
de Greef, Tom F. A.
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Biochemical reaction networks can exhibit plastic adaptation to alter their functions in response to environmental changes. This capability is derived from the structure and dynamics of the reaction networks and the functionality of the biomolecule. This plastic adaptation in biochemical reaction systems is essentially related to memory and learning capabilities, which have been studied in DNA computing applications for the past decade. However, designing DNA reaction systems with memory and learning capabilities using the dynamic properties of biochemical reactions remains challenging. In this study, we propose a basic DNA reaction system design that acquires classical conditioning, a phenomenon underlying memory and learning, as a typical learning task. Our design is based on a simple mechanism of five DNA strand displacement reactions and two degradative reactions. The proposed DNA circuit can acquire or lose a new function under specific conditions, depending on the input history formed by repetitive stimuli, by exploiting the dynamic properties of biochemical reactions induced by different input timings. |
|
言語 |
en |
| 書誌情報 |
en : ACS Synthetic Biology
巻 13,
号 2,
p. 521-529,
発行日 2024-01-27
|
| 出版社 |
|
|
出版者 |
American Chemical Society |
|
言語 |
en |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1021/acssynbio.3c00459 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2161-5063 |
| 著作権関連情報 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Copyright (c) 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0. |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
classical conditioning |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
learning |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
memory |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
forgetting |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
DNA strand displacement |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読の有無 |
|
|
値 |
yes |
| 研究者情報 |
|
|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/100000656_ja.html |
nakakuki-et-al-2024-dna-reaction-system-that-acquires-classical-conditioning.pdf (2.1 MB)
