| アイテムタイプ |
学術雑誌論文 = Journal Article(1) |
| 公開日 |
2024-06-07 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| タイトル |
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|
タイトル |
Autonomous assembly and disassembly of gliding molecular robots regulated by a DNA-based molecular controller |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 著者 |
Kawamata, Ibuki
Nishiyama, Kohei
Matsumoto, Daiki
Ichiseki, Shosei
Keya, Jakia J.
Okuyama, Kohei
Ichikawa, Masatoshi
Kabir, Arif Md. Rashedul
佐藤, 佑介
Inoue, Daisuke
Murata, Satoshi
Sada, Kazuki
Kakugo, Akira
Nomura, Shin-ichiro M.
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In recent years, there has been a growing interest in engineering dynamic and autonomous systems with robotic functionalities using biomolecules. Specifically, the ability of molecular motors to convert chemical energy to mechanical forces and the programmability of DNA are regarded as promising components for these systems. However, current systems rely on the manual addition of external stimuli, limiting the potential for autonomous molecular systems. Here, we show that DNA-based cascade reactions can act as a molecular controller that drives the autonomous assembly and disassembly of DNA-functionalized microtubules propelled by kinesins. The DNA controller is designed to produce two different DNA strands that program the interaction between the microtubules. The gliding microtubules integrated with the controller autonomously assemble to bundle-like structures and disassemble into discrete filaments without external stimuli, which is observable by fluorescence microscopy. We believe this approach to be a starting point toward more autonomous behavior of motor protein–based multicomponent systems with robotic functionalities. |
|
言語 |
en |
| 書誌情報 |
en : Science Advances
巻 10,
号 22,
p. eadn4490,
発行日 2024-05-31
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| 出版社 |
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出版者 |
American Association for the Advancement of Science |
|
言語 |
en |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1126/sciadv.adn4490 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2375-2548 |
| 著作権関連情報 |
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|
権利情報 |
Copyright (c) 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. no claim to original U.S. Government Works. distributed under a creative commons Attribution license 4.0 (cc BY). |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読の有無 |
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|
値 |
yes |
| 研究者情報 |
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|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/100001534_ja.html |
| 論文ID（連携） |
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値 |
10435560 |
| 連携ID |
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|
値 |
12353 |
10435560.pdf (626 KB)
