| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-01-29 |
| タイトル |
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|
タイトル |
Initial bone tissue reactions of hydroxyapatite/collagen–(3-glycidoxypropyl)trimethoxysilane injectable bone paste |
|
言語 |
en |
| 著者 |
Sato, Taira
城崎, 由紀
Oshima, Sho
Tsuru, Kanji
Koyama, Yoshihisa
Aizawa, Mamoru
Kikuchi, Masanori
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| 著作権関連情報 |
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|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright (c) 2024 The Author(s). Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We have previously reported that a novel bioresorbable self-setting injectable bone paste composed of hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) and (3-glycidoxypropyl)trimethoxysilane (GPTMS) was successfully prepared and was replaced with new bone within 3 months of implantation in defects created in porcine tibia. In this study, the HAp/Col-GPTMS paste was implanted into bone defects in rat tibiae to investigate the initial kinetics and bone tissue response. Even though more than 35% of GPTMS molecules should be eluted rapidly from directly injected pastes according to previously reported cell culture tests, in this study, energy-dispersive X-ray spectrometry did not detect Si (GPTMS) deposition in tissues surrounding the paste at 1 day postimplantation. Further, no abnormal inflammatory responses were observed in the surrounding tissues over the test period for both directly injected and prehardened pastes. Companying these observations with the results of the previous animal test (in which the paste was fully resorbed and was substituted with new bone), the eluted GPTMS resolved in no harm in vivo from the initial to final (completely resorbed) stages. Material resorption rates calculated from X-ray microcomputed tomography (μ-CT) images decreased with increasing in GPTMS concentration. Histological observations indicated that tartrate-resistant acid phosphatase (TRAP) active cells, (assumed to be osteoclasts), exist on the periphery of pastes. This result suggested that the paste was resorbed by osteoclasts in the same way as the HAp/Col. Since a good correlation was observed between TRAP active areas in histological sections and material resorption rate calculated from μ-CT, the TRAP activity coverage ratio offers the possibility to estimate the osteoclastic resorption ratio of materials, which are replaced with bone via bone remodeling process. |
|
言語 |
en |
| 書誌情報 |
en : Journal of biomedical materials research. Part B, Applied biomaterials
巻 112,
号 8,
p. e35451,
発行日 2024-07-25
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| 出版社 |
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出版者 |
Wiley |
| キーワード |
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主題Scheme |
Other |
|
主題 |
(3-glycidoxypropyl)trimethoxysilane |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
bioresorbability evaluation |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
bone tissue reaction |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
hydroxyapatite/collagen |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
injectable bone paste |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/jbm.b.35451 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11881538 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1552-4973 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1552-4981 |
| 査読の有無 |
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値 |
yes |
| 研究者情報 |
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|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/100000586_ja.html |
| 論文ID（連携） |
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|
値 |
10443537 |
| 連携ID |
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|
値 |
12526 |
10443537.pdf (44.6 MB)
