| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-01-30 |
| タイトル |
|
|
タイトル |
DNA-Origami-Armored DNA Condensates |
|
言語 |
en |
| その他のタイトル |
|
|
その他のタイトル |
DNA‐origami‐armored DNA Condensates |
|
言語 |
en |
| 著者 |
Yamashita, Nagi
佐藤, 佑介
Suzuki, Yuki
Ishikawa, Daisuke
Takinoue, Masahiro
|
| 著作権関連情報 |
|
|
権利情報 |
Copyright (c) 2024 The Authors. |
| 著作権関連情報 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
ChemBioChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
DNA condensates, formed by liquid-liquid phase separation (LLPS), emerge as promising soft matter assemblies for creating artificial cells. The advantages of DNA condensates are their molecular permeability through the surface due to their membrane-less structure and their fluidic property. However, they face challenges in the design of their surface, e.g., unintended fusion and less regulation of permeable molecules. Addressing them, we report surface modification of DNA condensates with DNA origami nanoparticles, employing a Pickering-emulsion strategy. We successfully constructed core-shell structures with DNA origami coatings on DNA condensates and further enhanced the condensate stability toward fusion via connecting DNA origamis by responding to DNA input strands. The ‘armoring’ prevented the fusion of DNA condensates, enabling the formation of multicellular-like structures of DNA condensates. Moreover, the permeability was altered through the state change from coating to armoring the DNA condensates. The armored DNA condensates have significant potential for constructing artificial cells, offering increased surface stability and selective permeability for small molecules while maintaining compartmentalized space and multicellular organization. |
|
言語 |
en |
| 書誌情報 |
en : ChemBioChem
巻 25,
号 20,
p. e202400468,
発行日 2024-07-29
|
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/cbic.202400468 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1439-4227 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1439-7633 |
| 査読の有無 |
|
|
値 |
yes |
| 研究者情報 |
|
|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/100001534_ja.html |
| 論文ID（連携） |
|
|
値 |
10443776 |
| 連携ID |
|
|
値 |
12573 |
10443776.pdf (2.9 MB)
