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Synthesis of cNDI-Peptide-Dimer as a G4 Cluster-Selective Binder and its Interaction with G4 Dimer
http://hdl.handle.net/10228/0002001203
http://hdl.handle.net/10228/000200120366b75d47-eda1-406b-9724-57803785a537
| 名前 / ファイル | ライセンス | アクション |
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10443849.pdf (1.5 MB)
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| アイテムタイプ | 共通アイテムタイプ(1) | |||||||||||||||
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| 公開日 | 2025-01-31 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Synthesis of cNDI-Peptide-Dimer as a G4 Cluster-Selective Binder and its Interaction with G4 Dimer | |||||||||||||||
| 言語 | en | |||||||||||||||
| 著者 |
Ono, Kentaro
× Ono, Kentaro
× 佐藤, しのぶ
WEKO
5963
× 竹中, 繁織
WEKO
6749
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| 著作権関連情報 | ||||||||||||||||
| 権利情報 | Copyright (c) 2024 The Authors. Chemistry Select published by Wiley-VCH GmbH. | |||||||||||||||
| 著作権関連情報 | ||||||||||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||
| 権利情報 | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | The amino acid unit carrying cyclic naphthalene diimide (cNDI) was synthesized by linking the amino moiety of cNDI as a G4-specific ligand with the γ-carboxylic acid moiety of Fmoc-Glu. cNDI-peptide-dimer, 1 was synthesized by peptide synthesizer using this unit. 1 exhibited an extremely strong binding constant of the order of 10 8 M-1 with telomeric G4 dimer, probably due to cooperative stacking of the its two G4 planes. It also showed an IC50 at the nM level by the TRAP assay. The results obtained here are expected to enable the design of peptide ligands with multiple cNDI sites targeting the G4 cluster by using the amino acid units of cNDI. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 書誌情報 |
en : ChemistrySelect 巻 9, 号 16, p. e202401062, 発行日 2024-04-19 |
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| 出版社 | ||||||||||||||||
| 出版者 | Wiley | |||||||||||||||
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| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| DOI | ||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1002/slct.202401062 | |||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 2365-6549 | |||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2365-6549 | |||||||||||||||
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| 値 | yes | |||||||||||||||
| 研究者情報 | ||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/395_ja.html | |||||||||||||||
| 論文ID（連携） | ||||||||||||||||
| 値 | 10443849 | |||||||||||||||
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| 値 | 12599 | |||||||||||||||
