| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-02-04 |
| タイトル |
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|
タイトル |
Loading of antibiotic molecules into organically modified layered calcium silicate |
|
言語 |
en |
| 著者 |
Nakamura, Jin
Kato, Hina
宮崎, 敏樹
Ohtsuki, Chikara
|
| 著作権関連情報 |
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|
権利情報 |
Copyright (c) 2024 The Author(s). |
| 著作権関連情報 |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The Korean Ceramic Society and The Ceramic Society of Japan. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Calcium silicate is the basic component of bioactive materials that directly bond to living bone (bone-bonding property) in the body environment because calcium silicate can easily form a hydroxyapatite layer on its surface after exposure to body fluids. The organic modification of calcium silicate ceramics is expected to improve their physicochemical properties. Organic modifications of layered inorganic substances have been studied to allow drug loading and sustained release through structural changes. However, few studies have investigated the effect of organic modifications on drug-release carriers. In this study, layered calcium silicate hydrate (C-S-H) prepared via a hydrothermal process was chemically modified with alkyl groups using alkoxysilane. In addition, the loading behavior of the antibiotic levofloxacin was quantitatively analyzed. Structural analysis of the synthesized samples indicated that the interlayer distance and amount of organic content in C-S-H increased with increasing carbon chain length and concentration of alkoxysilane. Levofloxacin was successfully incorporated into the modified C-S-H. It has been suggested that drug incorporation occurs mainly via surface adsorption rather than intercalation into the interlayer. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Asian Ceramic Societies
巻 12,
号 3,
p. 227-233,
発行日 2024-05-16
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| 出版社 |
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出版者 |
Taylor & Francis |
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言語 |
en |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Layered calcium silicate hydrate (C-S-H) |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
drug loading |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
interlayer distance |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
alkoxysilane |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
organic modification |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1080/21870764.2024.2352202 |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2187-0764 |
| 研究者情報 |
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|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html |
| 論文ID（連携） |
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|
値 |
10445001 |
| 連携ID |
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|
値 |
12744 |
10445001.pdf (2.1 MB)
