| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-02-18 |
| タイトル |
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|
タイトル |
Self-assembling into nanostructure of Cu-Ag NPs with both enhanced antimicrobial activity and cytocompatibility |
|
言語 |
en |
| 著者 |
Zeng, Guoan
Liao, Shichao
Liu, Jinkun
Zhu, Yan
宮崎, 敏樹
|
| 著作権関連情報 |
|
|
権利情報 |
Copyright (c) 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The germ-killing functions of silver and copper nanoparticles (NPs) were worthy of biomedical applications, but as heavy metals, NPs need to be more antimicrobial at lower doses to minimize hazards to human health, which requires more explorations on the new structures resulting from the compositing between two metals. In this study, self-assembled Cu-Ag bimetallic NPs were synthesized using a two-step reduction method. Results showed that both the Cu and Ag in Cu-Ag NPs existed as pure phases, the nanoparticles comprised ∼5 nm primary particles that self-assembled into ∼50 nm secondary particles surrounded with carbon-chain coatings. The larger secondary particles provided Cu-Ag with good particle dispersibility and chemical stability against deeper oxidation above ∼360 °C, while the smaller primary particles facilitated their suspensions in achieving a maximum inhibition ring of 10.01±0.25 mm and a minimum optical density (OD) of 0.11±0.01. Cu-Ag NPs demonstrated superior antimicrobial performance against all target strains, exhibiting synergistic enhancement through released active ions and reactive oxygen species (ROS). Cell viability ranged from 74.4 % to 95.4 % after co-culturing for 24 h, confirming that all synthesized nanometals were non-toxic to L929 cells at most concentrations. Increasing the suspension concentration enhanced antimicrobial activity while reducing cell viability. This conflict established an optimal Cu/Ag ratio of 10:4 and a concentration of 4 μg/mL, allowing Cu-Ag NPs to perform both broad-spectrum bactericidal activity and cell safety. |
|
言語 |
en |
| 書誌情報 |
en : Materials Today Communications
巻 41,
p. 110743,
発行日 2024-10-21
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| 出版社 |
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出版者 |
Elsevier |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cu-Ag nanoparticles |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Self-assembled structure |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Anti-oxidation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Antimicrobial performances |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Cytotoxicity |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.mtcomm.2024.110743 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2352-4928 |
| 研究者情報 |
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|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html |
| 論文ID（連携） |
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|
値 |
10448596 |
| 連携ID |
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|
値 |
13029 |
10448596.pdf (2 MB)
