| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-03-06 |
| タイトル |
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|
タイトル |
MLm5C: A high-precision human RNA 5-methylcytosine sites predictor based on a combination of hybrid machine learning models |
|
言語 |
en |
| その他のタイトル |
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|
その他のタイトル |
MLm5C: a high-precision human RNA 5-methylcytosine sites predictor based on a combination of hybrid machine learning models |
|
言語 |
en |
| 著者 |
倉田, 博之
Md Harun-Or-Roshid,
Md Mehedi Hasan,
Tsukiyama, Sho
前田, 和勲
Balachandran Manavalan,
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| 著作権関連情報 |
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権利情報 |
Copyright (c) 2024 Elsevier Inc. All rights reserved. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
RNA modification serves as a pivotal component in numerous biological processes. Among the prevalent modifications, 5-methylcytosine (m5C) significantly influences mRNA export, translation efficiency and cell differentiation and are also associated with human diseases, including Alzheimer’s disease, autoimmune disease, cancer, and cardiovascular diseases. Identification of m5C is critically responsible for understanding the RNA modification mechanisms and the epigenetic regulation of associated diseases. However, the large-scale experimental identification of m5C present significant challenges due to labor intensity and time requirements. Several computational tools, using machine learning, have been developed to supplement experimental methods, but identifying these sites lack accuracy and efficiency. In this study, we introduce a new predictor, MLm5C, for precise prediction of m5C sites using sequence data. Briefly, we evaluated eleven RNA sequence-derived features with four basic machine learning algorithms to generate baseline models. From these 44 models, we ranked them based on their performance and subsequently stacked the Top 20 baseline models as the best model, named MLm5C. The MLm5C outperformed the-state-of-the-art predictors. Notably, the optimization of the sequence length surrounding the modification sites significantly improved the prediction performance. MLm5C is an invaluable tool in accelerating the detection of m5C sites within the human genome, thereby facilitating in the characterization of their roles in post-transcriptional regulation. |
|
言語 |
en |
| 書誌情報 |
en : Methods
巻 227,
p. 37-47,
発行日 2024-05-14
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| 出版社 |
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出版者 |
Elsevier |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
RNA 5-methylcytosine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sequential forward search |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Baseline model |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sequence analysis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bioinformatics |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.ymeth.2024.05.004 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1046-2023 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1095-9130 |
| 研究者情報 |
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|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/100000926_ja.html |
| 論文ID（連携） |
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|
値 |
10435525 |
| 連携ID |
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|
値 |
12343 |
10435525.pdf (3.8 MB)
