| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-03-18 |
| タイトル |
|
|
タイトル |
In Situ Synthesis and Characterizations of a Strontium-Substituted Dicalcium Phosphate Anhydrous/Hydroxyapatite Biphasic Whisker and Its Properties Evaluation |
|
言語 |
en |
| 著者 |
Du, Weiye
Yang, Yunping
Liu, Jinkun
Zhu, Yan
Shen, Tao
Chen, Qinghua
宮崎, 敏樹
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Dicalcium phosphate anhydrous (DCPA) presents good biomineralization ability, the strontium element is known for superior bone affinity, and a whisker possesses good mechanical strength; all these are beneficial for improving the drawbacks of hydroxyapatite (HAP) like weaker mechanical properties, poor biomineralization, and slower degradation/absorption. Therefore, a homogeneous precipitation was adopted to synthesize Sr-substituted and DCPA and HAP coexisting whiskers. The composition, structure, and morphology based on urea dosage and substitution content were characterized, and the roles of DCPA, Sr, and whisker shape were investigated. It turned out that Sr-DCPA/HAP biphasic products contained about 19% DCPA and 81% HAP, and both phases occupied the outer and inner parts of the whisker, respectively. Increasing the urea dosage made the morphology transform from a sea urchin shape to fiber clusters and then whiskers, while Sr substitution brought the whisker back to the porous microsphere shape. Only 5% of Sr content and 15 g of urea could maintain the whisker shape. Sr could promote the proliferation of MC3T3-E1 cells even at a higher extract concentration of 10 mg/mL. The cells stayed in a healthy state whether cocultured with the whisker or the microsphere. The unstable DCPA combined with the decreased crystallinity brought by Sr doping contributed to shortening the apatite deposition period to within 7 days. The whisker morphology enhanced the compressive strength of acrylic resin, and the apatite layer helped to reduce the strength loss during soaking. The Sr-DCPA/HAP biphasic whisker with enhanced overall properties possessed more promising potential for biomedical application. |
|
言語 |
en |
| 書誌情報 |
en : ACS Biomaterials Science & Engineering
巻 10,
号 11,
p. 6874-6886,
発行日 2024-10-07
|
| 出版社 |
|
|
出版者 |
American Chemical Society |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
homogeneous precipitation method |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
DCPA/HAP biphasic whiskers |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
strontium substitution |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
in vitro biological properties |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
strength enhancement |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1021/acsbiomaterials.4c00306 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2373-9878 |
| 研究者情報 |
|
|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html |
| 論文ID（連携） |
|
|
値 |
10449740 |
| 連携ID |
|
|
値 |
13123 |
10449740.pdf (797.7 KB)
