| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-07-15 |
| タイトル |
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|
タイトル |
Fabrication and mechanical/biological evaluations of dissolving bird-bill microneedle arrays |
|
言語 |
en |
| 著者 |
Amano, Natsumi
Takaki, Yuusei
Takei, Harunori
Matsuo, Masaaki
Hara, Masaya
Tashiro, Yasunori
Oniki, Takahiro
伊藤, 高廣
引間, 知広
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| 著作権関連情報 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Copyright (c) The Author(s) 2024
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
|
言語 |
en |
| 抄録 |
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|
内容記述タイプ |
Abstract |
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内容記述 |
Coated microneedles (MNs) have several disadvantages, including limited drug doses, decreased skin puncture ability due to drug coating, and a risk of clogging and infection due to repeated application. We aimed to fabricate a dissolving bird-bill MN (dBB MN) with a vertical groove between two thin plate-shaped needles and needle pedestal. Moreover, we evaluated its ability to transdermally deliver a large-molecular-weight insulin into the systemic circulation. Hydrogels with various concentrations of polyvinylpyrrolidone (PVP) or sodium hyaluronate (HA) were prepared, and dBB MN arrays were fabricated by micromolding under negative pressure for potential mass production. The needle height of the dBB MN was at the maximum when the hydrogel was 25 w/w% PVP, with a viscosity of 8–9 Pa∙s. Furthermore, the buckling force of dBB MNs made from 25 w/w% PVP was 130.6 ± 51.0 mN, which increased to 195.6 ± 65.3 mN when insulin was added at 1 w/w%. The skin insertion ability of dBB MN was investigated using swain skin, with micro-holes were confirmed on the skin surface. dBB MN showed biphasic dissolution in the skin; the plate-shaped needles were immediately dissolved within 10 min, while the needle pedestal was slowly dissolved over 180 min. The blood glucose concentration in diabetic rats decreased slowly and significantly after a 3-h application of the insulin-loaded dBB MN array. Therefore, the dBB MN array demonstrated sufficient ability to puncture skin and transdermally deliver a large-molecular-weight drug into the systemic circulation. These findings suggest that the dBB MN array holds promise as a minimal invasive drug delivery platform, with potential applications in improving patient adherence and expanding access to essential therapies, particularly in resource-limited settings. |
|
言語 |
en |
| 書誌情報 |
en : Drug Delivery and Translational Research
巻 15,
p. 2581-2588,
発行日 2024-12-09
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| 出版社 |
|
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出版者 |
Springer |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bird-bill microneedle |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dissolving microneedle array |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Transdermal drug delivery |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Biocompatible polymer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Polyvinylpyrrolidone |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| DOI |
|
|
|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1007/s13346-024-01757-w |
| 助成情報 |
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|
|
助成機関名 |
日本学術振興会 |
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|
言語 |
ja |
|
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研究課題番号タイプ |
JGN |
|
|
研究課題番号 |
22K12846 |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22K12846/ |
|
|
研究課題名 |
烏口型マイクロニードルと物理的透過促進法による薬物皮膚透過速度制御システムの研究 |
|
|
言語 |
ja |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
2190-393X |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2190-3948 |
| 研究者情報 |
|
|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/285_ja.html |
| 論文ID（連携） |
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|
値 |
10461559 |
| 連携ID |
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|
値 |
14677 |
10461559.pdf (1.3 MB)
