| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-07-15 |
| タイトル |
|
|
タイトル |
Function and mechanism of hydrophilic drug-penetration enhancement using ultra-fine water particles on treated skin |
|
言語 |
en |
| 著者 |
Yasumoto, Yuki
Takeshita, Mayu
Inoue, Shinsuke
Tabata, Yuki
Shigemori, Yasushi
引間, 知広
|
| 著作権関連情報 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Copyright (c) 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The stratum corneum (SC), the outermost layer of the skin, serves as a significant barrier to transdermal drug delivery; therefore, effective penetration enhancers are critical for therapeutic applications. Ultra-fine water (UFW), a humidifier capable of generating nanometer-sized fine water particles, can improve skin barrier function, increase facial skin hydration, and enhance skin softness. However, its mechanism of action on the skin is not clear. Therefore, we aimed to clarify the effects of UFW on skin hydration and its penetration-enhancing properties for hydrophilic drug, particularly L-ascorbic acid 2-glucoside (AAG), and to investigate its mechanisms of action. In vitro studies demonstrated that UFW was rapidly absorbed into the SC, which maintained a higher water content than vapor-treated skin. AAG penetration studies revealed a mountainous flux profile with a peak at 15 min of UFW treatment, which significantly enhanced flux compared to that of untreated controls. A bilayer skin model was employed to calculate penetration parameters, diffusion coefficient and partition coefficient, in each layer, showing that UFW increased solubility in the SC and diffusivity in the viable skin (VS). Furthermore, extraction experiments confirmed that UFW facilitated the retention of AAG in the SC during the early stages of penetration and sustained its release over time. These findings suggest that UFW effectively enhances skin hydration and penetration of hydrophilic drugs, offering a safe and multifunctional tool for cosmetic and medical applications. Its unique properties make it a promising candidate for addressing challenges in transdermal drug delivery and skin treatment. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Drug Delivery Science and Technology
巻 112,
p. 107226,
発行日 2025-07-01
|
| 出版社 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Ultra-fine water |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Skin hydration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Stratum corneum |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Diffusivity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Solubility |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Skin penetration flux |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jddst.2025.107226 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1773-2247 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2588-8943 |
| 研究者情報 |
|
|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/285_ja.html |
| 論文ID（連携） |
|
|
値 |
10461560 |
| 連携ID |
|
|
値 |
14678 |
10461560.pdf (2.3 MB)
