| アイテムタイプ |
共通アイテムタイプ(1) |
| 公開日 |
2025-08-29 |
| タイトル |
|
|
タイトル |
A transphyletic study of metazoan β-catenin protein complexes |
|
言語 |
en |
| 著者 |
Mbogo, Ivan
Kawano, Chihiro
Nakamura, Ryotaro
Tsuchiya, Yuko
Villar-Briones, Alejandro
Hirao, Yoshitoshi
Yasuoka, Yuuri
早川, 英介
Tomii, Kentaro
Watanabe, Hiroshi
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| 著作権関連情報 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Copyright (c) The Author(s) 2024.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
|
言語 |
en |
| 著作権関連情報 |
|
|
権利情報Resource |
http://creativecommons.org/publicdomain/zero/1.0/ |
|
権利情報 |
The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Beta-catenin is essential for diverse biological processes, such as body axis determination and cell differentiation, during metazoan embryonic development. Beta-catenin is thought to exert such functions through complexes formed with various proteins. Although β-catenin complex proteins have been identified in several bilaterians, little is known about the structural and functional properties of β-catenin complexes in early metazoan evolution. In the present study, we performed a comparative analysis of β-catenin sequences in nonbilaterian lineages that diverged early in metazoan evolution. We also carried out transphyletic function experiments with β-catenin from nonbilaterian metazoans using developing Xenopus embryos, including secondary axis induction in embryos and proteomic analysis of β-catenin protein complexes. Comparative functional analysis of nonbilaterian β-catenins demonstrated sequence characteristics important for β-catenin functions, and the deep origin and evolutionary conservation of the cadherin–catenin complex. Proteins that co-immunoprecipitated with β-catenin included several proteins conserved among metazoans. These data provide new insights into the conserved repertoire of β-catenin complexes. |
|
言語 |
en |
| 書誌情報 |
en : Zoological Letters
巻 10,
号 20,
発行日 2024-12-02
|
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Β-catenin, Metazoan |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nematostella vectensis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Protein complex |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1186/s40851-024-00243-y |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2056-306X |
| 研究者情報 |
|
|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/100001775_ja.html |
| 論文ID（連携） |
|
|
値 |
10463480 |
| 連携ID |
|
|
値 |
14974 |
10463480.pdf (4.9 MB)
