{"created":"2025-09-02T12:00:13.969406+00:00","id":2001934,"links":{},"metadata":{"_buckets":{"deposit":"3539ecae-811b-458b-b2cf-24dec930bdde"},"_deposit":{"created_by":12,"id":"2001934","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"2001934"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:02001934","sets":["8:9"]},"author_link":["35430"],"control_number":"2001934","item_1736914626247":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1021/acssynbio.4c00889","subitem_relation_type_select":"DOI"}}]},"item_1736915800621":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2161-5063","subitem_source_identifier_type":"EISSN"}]},"item_1736918490417":{"attribute_name":"論文ID（連携）","attribute_value_mlt":[{"subitem_text_value":"10463501"}]},"item_1736918540808":{"attribute_name":"連携ID","attribute_value_mlt":[{"subitem_text_value":"14975"}]},"item_1736918590352":{"attribute_name":"研究者情報","attribute_value_mlt":[{"subitem_link_url":"https://hyokadb02.jimu.kyutech.ac.jp/html/279_ja.html"}]},"item_30002_alternative_title1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Azobenzene-modified temperature-responsive short elastin-like peptides for photo-controlled phase transition","subitem_alternative_title_language":"en"}]},"item_30002_bibliographic_information29":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-07-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"3012","bibliographicPageStart":"2999","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"ACS Synthetic Biology","bibliographic_titleLang":"en"}]}]},"item_30002_creator2":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suyama, Keitaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ngoc Mai, Elissa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"前田, 衣織","creatorNameLang":"ja"},{"creatorName":"Maeda, Iori","creatorNameLang":"en"}],"familyNames":[{"familyName":"前田","familyNameLang":"ja"},{"familyName":"Maeda","familyNameLang":"en"}],"givenNames":[{"givenName":"衣織","givenNameLang":"ja"},{"givenName":"Iori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"35430","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50311858","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000050311858"},{"nameIdentifier":"7006624951","nameIdentifierScheme":"Scopus著者ID","nameIdentifierURI":"https://www.scopus.com/authid/detail.uri?authorId=7006624951"},{"nameIdentifier":"0000-0001-5008-3412","nameIdentifierScheme":"ORCiD","nameIdentifierURI":"https://orcid.org/0000-0001-5008-3412"},{"nameIdentifier":"279","nameIdentifierScheme":"九工大研究者情報","nameIdentifierURI":"https://hyokadb02.jimu.kyutech.ac.jp/html/279_ja.html"}]},{"creatorNames":[{"creatorName":"Nose, Takeru","creatorNameLang":"en"}]}]},"item_30002_description9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Elastin-like peptides (ELPs) have attracted attention as temperature-responsive biomaterials that can be used as drug carriers. In this study, temperature- and photoresponsive self-assembling peptide analogues were developed by conjugating short ELPs (total 20 amino acid residues) and azobenzene derivatives. The synthesized ELP–azobenzene conjugates exhibited reversible spectral changes upon UV or visible-light irradiation and temperature-responsive phase separation in aqueous solutions. The aggregation ability of the trans-isomers of the ELP–azobenzene conjugates was stronger than that of the cis-isomers. This phenomenon was attributed to the change in the hydrophilicity of the azobenzene moiety associated with photoisomerization from the trans- to the cis-isomer. In addition, aggregates of the ELP–azobenzene conjugate could be controlled by light irradiation. Therefore, this study provides a methodology for photo- and temperature-responsive ELP analogues with low molecular weights that can be easily synthesized by simple chemical reactions and are potential candidates for drug carriers that enable precise control of drug release.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_30002_file35":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"10463501.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kyutech.repo.nii.ac.jp/record/2001934/files/10463501.pdf"},"version_id":"a7c891f8-2ee4-4e35-953e-19e28ed2bbc7"}]},"item_30002_funding_reference21":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"JP20K20202","subitem_award_number_type":"JGN","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K20202/"},"subitem_award_titles":[{"subitem_award_title":"光に応答して可逆的自己凝集を示すペプチドを用いた光線力学療法の薬物送達担体の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Development of drug delivery carriers for photodynamic therapy using peptides exhibiting photoresponsive reversible self-aggregation","subitem_award_title_language":"en"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会 (JSPS)","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science (JSPS)","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"JP22K12819","subitem_award_number_type":"JGN","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K12819/"},"subitem_award_titles":[{"subitem_award_title":"光照射により薬物包含・放出を制御可能な光線力学療法用ペプチド性薬物送達担体の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Development of peptide drug delivery carrier for photodynamic therapy that can control drug release by light irradiation","subitem_award_title_language":"en"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会 (JSPS)","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science (JSPS)","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"24K03120","subitem_award_number_type":"JGN","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K03120/"},"subitem_award_titles":[{"subitem_award_title":"環境水中の有害化学物質除去に資する環境調和型温度応答性ペプチド素材の設計と応用","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会 (JSPS)","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science (JSPS)","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"E&C HealthCare Ltd.","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"ECC Co., Ltd.","subitem_funder_name_language":"en"}]}]},"item_30002_language12":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_publisher10":{"attribute_name":"出版社","attribute_value_mlt":[{"subitem_publisher":"American Chemical Society","subitem_publisher_language":"en"}]},"item_30002_resource_type13":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30002_rights6":{"attribute_name":"著作権関連情報","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2025 The Authors. Published by American Chemical Society","subitem_rights_language":"en"}]},"item_30002_subject8":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Elastin-Like Peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Photoresponsive Peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phase Separation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Temperature-Responsive Peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Repetitive Sequence","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30002_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Azobenzene-Modified Temperature-Responsive Short Elastin-like Peptides for Photo-Controlled Phase Transition","subitem_title_language":"en"}]},"item_30002_version_type15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_title":"Azobenzene-Modified Temperature-Responsive Short Elastin-like Peptides for Photo-Controlled Phase Transition","item_type_id":"40001","owner":"12","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-09-02"},"publish_date":"2025-09-02","publish_status":"0","recid":"2001934","relation_version_is_last":true,"title":["Azobenzene-Modified Temperature-Responsive Short Elastin-like Peptides for Photo-Controlled Phase Transition"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2025-09-03T01:48:05.011464+00:00"}