WEKO3
アイテム
Bone formation on apatite-coated titanium with incorporated BMP-2/heparin in vivo
http://hdl.handle.net/10228/4809
http://hdl.handle.net/10228/4809f5f47761-0f87-47cd-ab87-528be0e5cfd7
| 名前 / ファイル | ライセンス | アクション |
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Ishibe.pdf (1.4 MB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||||||||||
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| 公開日 | 2011-01-24 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Bone formation on apatite-coated titanium with incorporated BMP-2/heparin in vivo | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 著者 |
Ishibe, Toru
× Ishibe, Toru× Goto, Tetsuya× Kodama, Takashi× 宮崎, 敏樹
WEKO
6369
× Kobayashi, Shigeru× Takahashi, Tetsu |
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Objective The objective of this study was to investigate whether the in vivo osteoinductive activity of an implant material is enhanced by covering the surface of apatite with incorporated bone morphogenetic protein 2 (BMP-2) and heparin which maintains the activity of BMP-2. Study design Titanium implants were alkaline treated, heat activated, and soaked in stimulated body fluid with or without BMP-2/heparin to coat the apatite around them. Treated implant bars were then implanted in rat tibiae. After 3 weeks, nondecalcified sections were prepared and the new bone formation around the implants was examined. Results A greater amount of bone formed on the apatite-coated implants containing BMP-2/heparin than on apatite-coated implants containing BMP, with ≥3 μg/mL heparin. Apatite-coated titanium implants with BMP-2/heparin had significantly enhanced new endosteal bone formation, with increases vertically (134%) and horizontally (124%). Conclusions Bone formation was stimulated around the apatite-covered titanium coated with BMP-2/heparin, which may be useful in improving implant therapy. |
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| 言語 | en | |||||||||||||
| 書誌情報 |
en : Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 巻 108, 号 6, p. 867-875, 発行日 2009-12 |
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| 出版者 | Elsevier | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.tripleo.2009.06.039 | |||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 1079-2104 | |||||||||||||
| 著作権関連情報 | ||||||||||||||
| 権利情報 | Copyright © 2009 Mosby, Inc. All rights reserved. | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 査読の有無 | ||||||||||||||
| 値 | yes | |||||||||||||
| 研究者情報 | ||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||
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| 値 | 65 | |||||||||||||
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| 値 | 897617A55FF9BBBA4925780700173E63 | |||||||||||||
