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Two-phase search (TPS) method : Nonbiased and high-speed parameter search for dynamic models of biochemical networks
http://hdl.handle.net/10228/5573
http://hdl.handle.net/10228/5573e4714d8e-c72c-4d27-946d-a28522506a2c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IPSJ2_2.pdf (2.4 MB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2016-02-03 | |||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Two-phase search (TPS) method : Nonbiased and high-speed parameter search for dynamic models of biochemical networks | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
| 著者 |
前田, 和勲
× 前田, 和勲
WEKO
16743
× 倉田, 博之
WEKO
2130
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Dynamic simulations are essential for understanding the mechanism of how biochemical networks generate robust properties to environmental stresses or genetic changes. However, typical dynamic modeling and analysis yield only local properties regarding a particular choice of plausible values of kinetic parameters, because it is hard to measure the exact values in vivo. Global and firm analyses are needed that consider how the changes in parameter values affect the results. A typical solution is to systematically analyze the dynamic behaviors in large parameter space by searching all plausible parameter values without any biases. However, a random search needs an enormous number of trials to obtain such parameter values. Ordinary evolutionary searches swiftly obtain plausible parameters but the searches are biased. To overcome these problems, we propose the two-phase search method that consists of a random search and an evolutionary search to effectively explore all possible solution vectors of kinetic parameters satisfying the target dynamics. We demonstrate that the proposed method enables a nonbiased and high-speed parameter search for dynamic models of biochemical networks through its applications to several benchmark functions and to the E. coli heat shock response model. | |||||||||||||||||||||
| 書誌情報 |
IPSJ Transaction on Bioinformatics 号 2, p. 2-14, 発行日 2009-03-24 |
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| 出版者 | 社団法人情報処理学会 | |||||||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2197/ipsjtbio.2.2 | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 1882-6679 | |||||||||||||||||||||
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| 権利情報 | Copyright (c) 2009 by the Information Processing Society of Japan | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
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| 値 | yes | |||||||||||||||||||||
| 研究者情報 | ||||||||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/265_ja.html | |||||||||||||||||||||
| 連携ID | ||||||||||||||||||||||
| 値 | 5315 | |||||||||||||||||||||
