@article{oai:kyutech.repo.nii.ac.jp:00004462,
 author = {Md., Monirul Islam and Fujii, Satoshi and Sato, Shinobu and 佐藤, しのぶ and Okauchi, Tatsuo and 岡内, 辰夫 and Takenaka, Shigeori and 竹中, 繁織},
 issue = {6},
 journal = {Molecules},
 month = {Jun},
 note = {A cyclic naphthalene diimide (cyclic NDI, 1), carrying a benzene moiety as linker chain, was synthesized and its interaction with G-quadruplex DNAs of a-core and a-coreTT as a human telomeric DNA, c-kit and c-myc as DNA sequence at promoter region, or thrombin-binding aptamer (TBA) studied based on UV-VIS and circular dichroism (CD) spectroscopic techniques, thermal melting temperature measurement, and FRET-melting assay. The circular dichroism spectra showed that 1 induced the formation of different types of G-quadruplex DNA structure. Compound 1 bound to these G-quadruplexes with affinities in the range of 106–107 M−1 order and a 2:1 stoichiometry. Compound 1 showed 270-fold higher selectivity for a-core than dsDNA with a preferable a-core binding than a-coreTT, c-kit, c-myc and TBA in the presence of K+, which is supported by thermal melting studies. The FRET-melting assay also showed that 1 bound preferentially to human telomeric DNA. Compound 1 showed potent inhibition against telomerase activity with an IC50 value of 0.9 μM and preferable binding to G-quadruplexes DNA than our previously published cyclic NDI derivative 3 carrying a benzene moiety as longer linker chain.},
 pages = {10963--10979},
 title = {A Selective G-Quadruplex DNA-Stabilizing Ligand Based on a Cyclic Naphthalene Diimide Derivative},
 volume = {20},
 year = {2015},
 yomi = {サトウ, シノブ and オカウチ, タツオ and タケナカ, シゲオリ}
}