WEKO3
アイテム
Sol-gel synthesis of magnetic TiO2 microspheres and characterization of their in vitro heating ability for hyperthermia treatment of cancer
http://hdl.handle.net/10228/5686
http://hdl.handle.net/10228/5686829ce0a2-8137-41a5-99d7-418c6e2834e6
| 名前 / ファイル | ライセンス | アクション |
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JSST-D-14-00694.pdf (1.1 MB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||||||||||
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| 公開日 | 2016-07-01 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Sol-gel synthesis of magnetic TiO2 microspheres and characterization of their in vitro heating ability for hyperthermia treatment of cancer | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | eng | |||||||||||||
| 著者 |
Liu, Gengci
× Liu, Gengci× Kawashita, Masakazu× Li, Zhixia× 宮崎, 敏樹
WEKO
6369
× Kanetaka, Hiroyasu |
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Common cancer treatments are invasive and lack specificity, leading to unwanted side effects. Because hyperthermia can kill cancer cells and damage proteins and structures within cells, it has been considered a novel, minimally invasive cancer treatment. However, many hyperthermia treatments cannot heat deep-seated tumors effectively and locally. Heat-generating magnetic microspheres can help address this challenge. However, current research has not produced microspheres that can be sufficiently heated. We prepared magnetic titania (TiO2) microspheres by introducing magnetite nanoparticles (MNPs) into the sol–gel process during water-in-oil emulsion for in situ hyperthermia treatment of cancers. Two types of MNPs were used in this study: One type was synthesized by a chemical coprecipitation method, and the other type was commercially available MNPs. The obtained microspheres contained up to 46.7 wt% MNPs, and their saturation magnetization and coercive force were 34.2 emu/g and 103 Oe, respectively. The particles’ in vitro heating efficiency in an agar phantom was measured in an alternating magnetic field of 300 Oe and 100 kHz. The temperature increase in the agar phantom within 300 s was 4.5 °C for microspheres with MNPs that were synthesized by chemical coprecipitation and 53 °C for microspheres with commercially available MNPs. The excellent heating efficiency of the microspheres may be attributed to the hysteresis losses of the magnetic particles. These microspheres are believed to be promising thermoseeds for hyperthermic treatment of cancer. | |||||||||||||
| 言語 | en | |||||||||||||
| 書誌情報 |
Journal of Sol-Gel Science and Technology 巻 75, 号 1, p. 90-97, 発行日 2015-07-01 |
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| 出版社 | ||||||||||||||
| 出版者 | Springer | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1007/s10971-015-3680-x | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0928-0707 | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 1573-4846 | |||||||||||||
| 著作権関連情報 | ||||||||||||||
| 権利情報 | Springer | |||||||||||||
| 著作権関連情報 | ||||||||||||||
| 権利情報 | The final publication is available at link.springer.com/article/10.1007/s10971-015-3680-x. | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Sol–gel process | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Magnetite | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Titania microspheres | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Hyperthermia treatment of cancer | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 査読の有無 | ||||||||||||||
| 値 | yes | |||||||||||||
| 研究者情報 | ||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||
| 連携ID | ||||||||||||||
| 値 | 5264 | |||||||||||||
