WEKO3
アイテム
Apatite mineralization behavior on polyglutamic acid hydrogels in aqueous condition : effects of molecular weight
http://hdl.handle.net/10228/5924
http://hdl.handle.net/10228/592487fe5fbe-c066-4282-91ab-876865f3e5ea
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BMME23_339Fig.pdf (392.2 kB)
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BMME23_339.pdf (54.5 kB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||||||||||
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| 公開日 | 2016-12-02 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Apatite mineralization behavior on polyglutamic acid hydrogels in aqueous condition : effects of molecular weight | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 著者 |
宮崎, 敏樹
× 宮崎, 敏樹
WEKO
6369
× Mukai, Juntarou× Ishida, Eiichi× Ohtsuki, Chikara |
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Apatite-polymer composites mimicking specific structure of natural bone are promised as bone substitutes with moderate flexibility able to be fabricated into desired shapes as well as bone-bonding bioactivity. In order to precipitate the apatite on polymer surfaces, aqueous processing using solution supersaturated to the apatite has been attracting as much attention. Polyglutamic acid (PGA) is a promised candidate of the polymer, since it has high apatite-forming ability owing to abundant carboxyl groups able to trigger the heterogeneous apatite nucleation. Although combination of PGA with different molecular weight is expected to provide design of organic-inorganic composites with moderate bioresorbability, precise relationship between the molecular weight of the PGA and its apatite-forming ability has been remained unclear. In the present study, PGA hydrogels with different molecular weight were prepared by covalent cross-linking using ethylenediamine. Difference in apatite formation in simulated body fluid (SBF) was interpreted in terms of their chemical structure. It was found that hydrogels prepared from PGA with higher molecular weight showed tendency to have higher apatite-forming ability. It was attributed to high content of the carboxyl group remaining on the hydrogel due to low degree of the cross-linking. | |||||||||||||
| 言語 | en | |||||||||||||
| 書誌情報 |
en : Bio-Medical Materials and Engineering 巻 23, 号 5, p. 339-347, 発行日 2013-08 |
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| 出版社 | ||||||||||||||
| 出版者 | IOS Press | |||||||||||||
| 言語 | en | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.3233/BME-130758 | |||||||||||||
| NCID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA1076721X | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 1878-3619 | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0959-2989 | |||||||||||||
| 著作権関連情報 | ||||||||||||||
| 権利情報 | The final publication is available at IOS Press through http://dx.doi.org/10.3233/BME-130758 | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Polyglutamic acid (PGA) | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | apatite | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | simulated body fluid (SBF) | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | molecular weight | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | organic–inorganic composites | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 査読の有無 | ||||||||||||||
| 値 | yes | |||||||||||||
| 研究者情報 | ||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||
| 連携ID | ||||||||||||||
| 値 | 5856 | |||||||||||||
