{"created":"2023-05-15T11:58:42.178545+00:00","id":4819,"links":{},"metadata":{"_buckets":{"deposit":"bd0e0681-a4c5-4e05-8d80-202414679a60"},"_deposit":{"created_by":3,"id":"4819","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4819"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:00004819","sets":["8:9"]},"author_link":["6369","17791","17789","17790","17788","17792"],"item_21_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-02-17","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"323","bibliographicPageStart":"317","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Materials Science and Engineering: C"}]}]},"item_21_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bioactive titania (TiO2) microparticles can be used as drug-releasing cement fillers for the chemotherapeutic treatment of metastatic bone tumors. Porous anatase-type TiO2 microspheres around 15 μm in diameter were obtained through a sol–gel process involving a water-in-oil emulsion with 30:70 SiO2/H2O weight ratio and subsequent NaOH solution treatment. The water phase consisted of methanol, titanium tetraisopropoxide, diethanolamine, SiO2 nanoparticles, and H2O, while the oil phase consisted of kerosene, Span 80, and Span 60. The resulting microspheres had a high specific surface area of 111.7 m2·g− 1. Apatite with a network-like surface structure formed on the surface of the microspheres within 8 days in simulated body fluid. The good apatite-forming ability of the microspheres is attributed to their porous structure and the negative zeta potential of TiO2. The release of rhodamine B, a model for a hydrophilic drug, was rapid for the first 6 h of soaking, but diffusion-controlled thereafter. The burst release in the first 6 h is problematic for clinical applications; nonetheless, the present results highlight the potential of porous TiO2 microspheres as drug-releasing cement fillers able to form apatite.","subitem_description_type":"Abstract"}]},"item_21_description_60":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_21_link_62":{"attribute_name":"研究者情報","attribute_value_mlt":[{"subitem_link_url":"https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html"}]},"item_21_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_21_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.msec.2015.02.017","subitem_relation_type_select":"DOI"}}]},"item_21_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2015 Elsevier B.V."}]},"item_21_select_59":{"attribute_name":"査読の有無","attribute_value_mlt":[{"subitem_select_item":"yes"}]},"item_21_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11537849","subitem_source_identifier_type":"NCID"}]},"item_21_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0928-4931","subitem_source_identifier_type":"ISSN"}]},"item_21_text_36":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Biomedical Engineering, Tohoku University"},{"subitem_text_value":"School of Engineering, Tohoku University"},{"subitem_text_value":"School of Engineering, Tohoku University"},{"subitem_text_value":"Graduate School of Biomedical Engineering, Tohoku University"},{"subitem_text_value":"School of Chemistry and Chemical Engineering, Guangxi University"},{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology"}]},"item_21_text_63":{"attribute_name":"連携ID","attribute_value_mlt":[{"subitem_text_value":"5848"}]},"item_21_version_type_58":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawashita, Masakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Yui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueno, Shoji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Liu, Gengci"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Zhixia"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Miyazaki, Toshiki","creatorNameLang":"en"},{"creatorName":"宮崎, 敏樹","creatorNameLang":"ja"},{"creatorName":"ミヤザキ, トシキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-17"}],"displaytype":"detail","filename":"MSEC50_317.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MSEC50_317.pdf","url":"https://kyutech.repo.nii.ac.jp/record/4819/files/MSEC50_317.pdf"},"version_id":"161873d8-1226-4350-8a9c-366d46127ff9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TiO2; Microsphere","subitem_subject_scheme":"Other"},{"subitem_subject":"Apatite","subitem_subject_scheme":"Other"},{"subitem_subject":"Rhodamine B","subitem_subject_scheme":"Other"},{"subitem_subject":"Bioactivity","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug-release","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vitro apatite formation and drug loading/release of porous TiO2 microspheres prepared by sol-gel processing with different SiO2 nanoparticle contents","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vitro apatite formation and drug loading/release of porous TiO2 microspheres prepared by sol-gel processing with different SiO2 nanoparticle contents"}]},"item_type_id":"21","owner":"3","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-17"},"publish_date":"2017-02-17","publish_status":"0","recid":"4819","relation_version_is_last":true,"title":["In vitro apatite formation and drug loading/release of porous TiO2 microspheres prepared by sol-gel processing with different SiO2 nanoparticle contents"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-04-02T08:42:33.720541+00:00"}