WEKO3
アイテム
Particle Simulation of Liver Cell Proliferation with Angiogenesis -Whole Hepatic Lobule Formation-
http://hdl.handle.net/10228/00006243
http://hdl.handle.net/10228/00006243de55694a-94e7-45b1-86ea-41bc4cb2997a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BME0002.pdf (451.1 kB)
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| アイテムタイプ | 会議発表論文 = Conference Paper(1) | |||||||||||
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| 公開日 | 2017-06-27 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||||||||
| 資源タイプ | conference paper | |||||||||||
| タイトル | ||||||||||||
| タイトル | Particle Simulation of Liver Cell Proliferation with Angiogenesis -Whole Hepatic Lobule Formation- | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 著者 |
Ogawa, Shinya
× Ogawa, Shinya× 永山, 勝也
WEKO
17054
× Shirakigawa, Nana× Ijima, Hiroyuki |
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The liver is the organ primarily responsible for our metabolism and loss of its function generally results in death. Luckily, the liver has a high regenerative ability. However, the mechanism of its regeneration has not yet been clarified. This study therefore models liver regeneration via a numerical simulation. In addition, this simulation may aid other experiments in the field of regenerative medicine. As a first step, this study proposes an analytical model based on the particle method. The analysis object is a hepatic lobule. The purpose of this analysis is to elucidate the process, mechanism, and condition of cell growth on the micro-scale. Experiments using rats were conducted to obtain the parameters for the model, namely the diffusivity, oxygen concentration, and oxygen consumption rate of a cell. The most difficult to solve problem in liver cell proliferation technology is the restricted volume in which cells survive owing to oxygen supply problems. It is therefore necessary to extend the cell survival volume by angiogenesis. Here, results were generated using a model of angiogenesis in which blood vessels formed from the portal veins to a central vein, with repeated branching and connecting across the whole of the liver. In this way a hepatic lobule was filled with liver cells. Additionally, the analysis results yielded the rates of the cross sectional areas of the blood vessels. This research further aims to analyze the macro region by using analysis results obtained on the micro-scale. Applying the thresholds which is the most closed to the experimental value obtained from analysis results on the micro-scale to the macro region, it becomes available to curtail expenses and be kind to animals in the liver experiments. | |||||||||||
| 備考 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | The 7th International Conference on Mechanical Engineering (TSME-ICoME 2016), 13-16 December 2016, Chiang Mai, Thailand. | |||||||||||
| 書誌情報 |
Proceedings of The 7th TSME International Conference on Mechanical Engineering 巻 2016, p. BME0002, 発行日 2016-12-14 |
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| 出版社 | ||||||||||||
| 出版社 | Chulalongkorn University | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Particle Simulation | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Liver proliferation | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Angiogenesis | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 査読の有無 | ||||||||||||
| 値 | yes | |||||||||||
| 研究者情報 | ||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/256_ja.html | |||||||||||
| 論文ID（連携） | ||||||||||||
| 値 | 10302729 | |||||||||||
| 連携ID | ||||||||||||
| 値 | 6176 | |||||||||||
