WEKO3
アイテム
歯周病抑制のための歯周病原菌とプロバイオティクス菌乳酸菌群の生理動態の理解
https://doi.org/10.18997/00006547
https://doi.org/10.18997/000065477132d88c-3b68-4866-a22e-96e693f60773
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
sei_k_276.pdf (4.3 MB)
|
|
| アイテムタイプ | 学位論文 = Thesis or Dissertation(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2018-02-05 | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| タイトル | ||||||||
| タイトル | Understanding Physiological Dynamics of Periodontal Pathogens and Potential Probiotics, Lactobacillus spp. to Prevent Periodontal Disease | |||||||
| 言語 | en | |||||||
| タイトル | ||||||||
| タイトル | 歯周病抑制のための歯周病原菌とプロバイオティクス菌乳酸菌群の生理動態の理解 | |||||||
| 言語 | ja | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 著者 |
Norzawani, Jaffar
× Norzawani, Jaffar
|
|||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Combinations of periodontal infection and destructive immune response are contributive factors to aggressive periodontitis and gingivitis, resulting in a poor prognosis to periodontal disease （Pihlstrom et al. 2005）. Probiotic application using lactobacilli can be promising to counteract the periodontal disease. Probiotic owns unique properties and expresses beneficial roles in improving systemic health and also reducing the incidence of dental caries （Haukioja 2010）. Hence, the main purpose of my Ph.D. study is to evaluate the dynamic of probiotic lactobacilli in the interaction with the periodontal pathogen and innate immune cells in denoting a positive role to prevent the periodontal disease. In this study, dynamic of periodontal pathogens and probiotic lactobacilli were evaluated via the following 4 approaches; 1） Inhibitive interaction between probiotic lactobacilli and periodontal pathogens via direct and indirect co-culture approaches, 2） Counteraction for the mature biofilm of the periodontal pathogens, Aggregatibacter actinomycetemcomitans strains by the potential probiotic lactobacilli, 3） understanding the biofilm formation of periodontal pathogens on hydroxyapatite surfaces, and 4） activation of phagocytic function by probiotic lactobacilli in combating A. actinomycetemcomitans infection. Our finding shows, 1） different interaction of inhibition was found in the direct and indirect co-culture method, by which significant bactericidal activity by certain species of probiotic lactobacilli was observed in the indirect approach, whereas direct co-culture showed vice versa, 2） probiotic lactobacilli were potently degrading the matured formed-biofilm of A. actinomycetemcomitans strains, 3） varied effect of biofilm formation on the hydroxyapatite surfaces were observed between two periodontal pathogen species incorporated with complex calcium intake, 4） probiotic lactobacilli showed the potential to induce the murine macrophage polarization prior A. actinomycetemcomitans Y4 infection. In conclusion, probiotic lactobacilli has found to own beneficial role against the periodontal pathogens activity and modulate the macrophage activity toward prevention of periodontal disease. This findings are indeed important in providing essential information on the physiological dynamics of periodontal pathogen and probiotic lactobacilli, meanwhile characterized the new insight into how probiotic lactobacilli roles to counteract the activities of the periodontal pathogen and modulate the innate immune system towards a preventive mode of periodontal disease. | |||||||
| 目次 | ||||||||
| 内容記述タイプ | TableOfContents | |||||||
| 内容記述 | 1 Introduction and literature review|| 2 General materials and methods|| 3 Interaction of probiotic bacteria with periodontal pathogen|| 4 Mature biofilm degradation by potential probiotics: Aggregatibacter actinomycetemcomitans VERSUS Lactobacillus spp.|| 5 Biofilm formation of periodontal pathogens on hydroxyapatite surfaces: implications for periodontium damage|| 6 Probiotic induce phagocytic killing of A. actinomycetemcomitans Y4 in raw264.7 murine macrophage cells|| 7 Concluding remaks and suggestion for future research | |||||||
| 備考 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 九州工業大学博士学位論文 学位記番号:生工博甲第276号 学位授与年月日:平成28年12月27日 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Probiotics | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Periodontal pathogens Lactobacillus | |||||||
| アドバイザー | ||||||||
| 前田, 憲成 | ||||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第276号 | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（工学） | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2016-12-27 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 17104 | |||||||
| 学位授与機関名 | 九州工業大学 | |||||||
| 学位授与年度 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 平成28年度 | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| ID登録 | ||||||||
| ID登録 | 10.18997/00006547 | |||||||
| ID登録タイプ | JaLC | |||||||
