{"created":"2023-05-15T11:59:29.537575+00:00","id":5930,"links":{},"metadata":{"_buckets":{"deposit":"bb89befa-76a2-4c5a-8939-8cbbc084b99a"},"_deposit":{"created_by":3,"id":"5930","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5930"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:00005930","sets":["8:24"]},"author_link":["24493","15664","6369","24490"],"item_21_alternative_title_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Structural effects of sulfur-containing functional groups on apatite formation on Ca2+-modified copolymers in a simulated body environment"}]},"item_21_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"5633","bibliographicPageStart":"5627","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"ACS Omega"}]}]},"item_21_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chemical modification with specific functional groups has been the conventional method to develop bone-bonding bioactive organic–inorganic hybrids. These materials are attractive as bone substitutes because they are flexible and have a Young’s modulus similar to natural bone. Immobilization of sulfonic acid groups (−SO3H) onto the polymer chain is expected to produce such hybrids because these groups induce apatite formation in a simulated body fluid (SBF) and enhance the activity of osteoblast-like cells. Sulfinic acid groups (−SO2H), which are derivatives of −SO3H, can also induce apatite nucleation. However, the structural effects of such sulfur-containing functional groups on apatite formation have not been elucidated. In the present study, apatite formation on Ca2+-modified copolymers containing −SO2H or −SO3H was investigated in a simulated body environment. The copolymer containing Ca2+ and −SO3H promoted Ca2+ release into the SBF and formed apatite faster (1 day) than the copolymer containing Ca2+ and −SO2H (14 days). In contrast, when they were not modified with Ca2+, the copolymer containing only −SO2H deposited the apatite faster (7 days) than that containing only −SO3H (>7 days) in the solution with Ca2+ concentration 1.5 times that of SBF. The former adsorbed larger amounts of Ca2+ than the latter. The measured stability constant of the complex indicated that the interaction of −SO2–···Ca2+ was more stable than that of −SO3–···Ca2+. It was found that both the release and adsorption of Ca2+ governed by the stability played an important role in induction of the apatite formation and that the apatite-forming ability of sulfur-containing functional groups drastically changed by the coexistence of Ca2+.","subitem_description_type":"Abstract"}]},"item_21_description_60":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_21_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"24493","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hamai,  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10.1021/acsomega.8b00694."}]},"item_21_select_59":{"attribute_name":"査読の有無","attribute_value_mlt":[{"subitem_select_item":"yes"}]},"item_21_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2470-1343","subitem_source_identifier_type":"ISSN"}]},"item_21_text_28":{"attribute_name":"論文ID（連携）","attribute_value_mlt":[{"subitem_text_value":"10318550"}]},"item_21_text_36":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4, Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan"},{"subitem_text_value":"Faculty of Engineering, Kyushu Institute of Technology, 1-1, Sensui-cho, Tobata-ku, Kitakyushu 804-8550, Japan"},{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4, Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, 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