{"created":"2023-05-15T11:59:34.675819+00:00","id":6063,"links":{},"metadata":{"_buckets":{"deposit":"c5cc28f4-2372-4b60-b881-090ef9c15811"},"_deposit":{"created_by":3,"id":"6063","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6063"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:00006063","sets":["8:9"]},"author_link":["24878","24877","24880"],"item_21_alternative_title_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Limitations of a Metabolic Network-Based Reverse Ecology Method for Inferring Host–Pathogen Interactions"}]},"item_21_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"278-9","bibliographicPageStart":"278-1","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"BMC Bioinformatics"}]}]},"item_21_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background Host–pathogen interactions are important in a wide range of research fields. Given the importance of metabolic crosstalk between hosts and pathogens, a metabolic network-based reverse ecology method was proposed to infer these interactions. However, the validity of this method remains unclear because of the various explanations presented and the influence of potentially confounding factors that have thus far been neglected. Results We re-evaluated the importance of the reverse ecology method for evaluating host–pathogen interactions while statistically controlling for confounding effects using oxygen requirement, genome, metabolic network, and phylogeny data. Our data analyses showed that host–pathogen interactions were more strongly influenced by genome size, primary network parameters (e.g., number of edges), oxygen requirement, and phylogeny than the reserve ecology-based measures. Conclusion These results indicate the limitations of the reverse ecology method; however, they do not discount the importance of adopting reverse ecology approaches altogether. Rather, we highlight the need for developing more suitable methods for inferring host–pathogen interactions and conducting more careful examinations of the relationships between metabolic networks and host–pathogen interactions.","subitem_description_type":"Abstract"}]},"item_21_description_60":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal 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Central"}]},"item_21_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1186/s12859-017-1696-7","subitem_relation_type_select":"DOI"}}]},"item_21_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1186/s12859-017-1696-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12859-017-1696-7","subitem_relation_type_select":"DOI"}}]},"item_21_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) The Author(s). 2017"},{"subitem_rights":"Creative Commons Attribution 4.0 International License"},{"subitem_rights":"http://creativecommons.org/licenses/by/4.0/"}]},"item_21_select_59":{"attribute_name":"査読の有無","attribute_value_mlt":[{"subitem_select_item":"yes"}]},"item_21_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1471-2105","subitem_source_identifier_type":"ISSN"}]},"item_21_text_28":{"attribute_name":"論文ID（連携）","attribute_value_mlt":[{"subitem_text_value":"10302343"}]},"item_21_text_36":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka 820-8502, Japan"},{"subitem_text_value":"Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka 820-8502, Japan"}]},"item_21_text_63":{"attribute_name":"連携ID","attribute_value_mlt":[{"subitem_text_value":"7792"}]},"item_21_version_type_58":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Takemoto, Kazuhiro","creatorNameLang":"en"},{"creatorName":"竹本, 和広","creatorNameLang":"ja"},{"creatorName":"タケモト, カズヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{},{},{}]},{"creatorNames":[{"creatorName":"Aie,  Kazuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-03"}],"displaytype":"detail","filename":"s12859-017-1696-7.pdf","filesize":[{"value":"528.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s12859-017-1696-7.pdf","url":"https://kyutech.repo.nii.ac.jp/record/6063/files/s12859-017-1696-7.pdf"},"version_id":"c16339a3-dbd6-4253-9a88-ac954c0718dd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Reverse ecology","subitem_subject_scheme":"Other"},{"subitem_subject":"Metabolic networks","subitem_subject_scheme":"Other"},{"subitem_subject":"Species–species interactions","subitem_subject_scheme":"Other"},{"subitem_subject":"Systems biology","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Limitations of a metabolic network-based reverse ecology method for inferring host-pathogen interactions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Limitations of a metabolic network-based reverse ecology method for inferring host-pathogen interactions"}]},"item_type_id":"21","owner":"3","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-03"},"publish_date":"2019-07-03","publish_status":"0","recid":"6063","relation_version_is_last":true,"title":["Limitations of a metabolic network-based reverse ecology method for inferring host-pathogen interactions"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-04-02T08:32:56.954398+00:00"}