@article{oai:kyutech.repo.nii.ac.jp:00006089,
 author = {Saikiran,  Maryala and Sato,  Daisuke and Pandey, Shyam Sudhir and パンディ, シャム スディル and Hayase, Shuzi and 早瀬, 修二 and Kato, Tamaki and 加藤, 珠樹},
 issue = {17},
 journal = {Bioorganic & Medicinal Chemistry Letters},
 month = {Jul},
 note = {Extended wavelength analyte-responsive fluorescent probes are highly desired for the imaging applications owing to their deep tissue penetration, and minimum interference from autofluorescence by biomolecules. Near infra-red (NIR) sensitive and self-quenching fluorescent probe based on the dye-peptide conjugate (SQ 1 PC) was designed and synthesized by facile and efficient one-pot synthetic route for the detection of Elastase activity. In the phosphate buffer solution, there was an efficient quenching of fluorescence of SQ 1 PC (86%) assisted by pronounced dye-dye interaction due to H-aggregate formation. Efficient and fast recovery of this quenched fluorescence of SQ 1 PC (> 50% in 30 s) was observed on hydrolysis of this peptide-dye conjugate by elastase enzyme. Presently designed NIR sensitive self-quenching substrate offers the potential application for the detection of diseases related to proteases by efficient and fast detection of their activities.},
 pages = {4024--4029},
 title = {Efficient near infrared fluorescence detection of elastase enzyme using peptide-bound unsymmetrical squaraine dye},
 volume = {27},
 year = {2017},
 yomi = {ハヤセ, シュウジ and カトウ, タマキ}
}