{"created":"2023-05-15T11:59:35.835388+00:00","id":6089,"links":{},"metadata":{"_buckets":{"deposit":"de07d688-3c53-4736-931d-7b22a14e0e22"},"_deposit":{"created_by":3,"id":"6089","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6089"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:00006089","sets":["8:24"]},"author_link":["25006","25466","21325","6311","25005"],"item_21_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"17","bibliographicPageEnd":"4029","bibliographicPageStart":"4024","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters"}]}]},"item_21_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Extended wavelength analyte-responsive fluorescent probes are highly desired for the imaging applications owing to their deep tissue penetration, and minimum interference from autofluorescence by biomolecules. Near infra-red (NIR) sensitive and self-quenching fluorescent probe based on the dye-peptide conjugate (SQ 1 PC) was designed and synthesized by facile and efficient one-pot synthetic route for the detection of Elastase activity. In the phosphate buffer solution, there was an efficient quenching of fluorescence of SQ 1 PC (86%) assisted by pronounced dye-dye interaction due to H-aggregate formation. Efficient and fast recovery of this quenched fluorescence of SQ 1 PC (> 50% in 30 s) was observed on hydrolysis of this peptide-dye conjugate by elastase enzyme. Presently designed NIR sensitive self-quenching substrate offers the potential application for the detection of diseases related to proteases by efficient and fast detection of their activities.","subitem_description_type":"Abstract"}]},"item_21_description_60":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal 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Ltd."}]},"item_21_select_59":{"attribute_name":"査読の有無","attribute_value_mlt":[{"subitem_select_item":"yes"}]},"item_21_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1079577X","subitem_source_identifier_type":"NCID"}]},"item_21_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1464-3405","subitem_source_identifier_type":"ISSN"}]},"item_21_text_28":{"attribute_name":"論文ID（連携）","attribute_value_mlt":[{"subitem_text_value":"10309948"}]},"item_21_text_36":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology"},{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology"},{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology"},{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology"},{"subitem_text_value":"Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology"}]},"item_21_text_63":{"attribute_name":"連携ID","attribute_value_mlt":[{"subitem_text_value":"6623"}]},"item_21_version_type_58":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saikiran,  Maryala"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato,  Daisuke"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Pandey, Shyam Sudhir","creatorNameLang":"en"},{"creatorName":"パンディ, シャム スディル","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Hayase, Shuzi","creatorNameLang":"en"},{"creatorName":"早瀬, 修二","creatorNameLang":"ja"},{"creatorName":"ハヤセ, シュウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Kato, Tamaki","creatorNameLang":"en"},{"creatorName":"加藤, 珠樹","creatorNameLang":"ja"},{"creatorName":"カトウ, タマキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-22"}],"displaytype":"detail","filename":"BMCL27_4024.pdf","filesize":[{"value":"427.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCL27_4024.pdf","url":"https://kyutech.repo.nii.ac.jp/record/6089/files/BMCL27_4024.pdf"},"version_id":"dea88b3b-93f1-4334-8e4c-6eda78ad35cc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Far-red squaraine dye","subitem_subject_scheme":"Other"},{"subitem_subject":"Aggregation","subitem_subject_scheme":"Other"},{"subitem_subject":"Fluorescent peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Self-quenching","subitem_subject_scheme":"Other"},{"subitem_subject":"Dye-peptide conjugate","subitem_subject_scheme":"Other"},{"subitem_subject":"Elastase detection","subitem_subject_scheme":"Other"},{"subitem_subject":"Bio imaging","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Efficient near infrared fluorescence detection of elastase enzyme using peptide-bound unsymmetrical squaraine dye","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficient near infrared fluorescence detection of elastase enzyme using peptide-bound unsymmetrical squaraine dye"}]},"item_type_id":"21","owner":"3","path":["24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-22"},"publish_date":"2019-07-22","publish_status":"0","recid":"6089","relation_version_is_last":true,"title":["Efficient near infrared fluorescence detection of elastase enzyme using peptide-bound unsymmetrical squaraine dye"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-10-25T10:02:20.895078+00:00"}