@article{oai:kyutech.repo.nii.ac.jp:00006106, author = {Sato, Shinobu and 佐藤, しのぶ and Takenaka, Shigeori and 竹中, 繁織}, journal = {Journal of Inorganic Biochemistry}, month = {Nov}, note = {Seven ferrocenyl naphthalene diimide (FND) ligands were synthesized. Each had a higher affinity for tetraplex DNA than for either single- or double-stranded DNA. The FND binding affinities were > 105 M− 1 in 0.10 M AcOH-AcONa or AcOH-AcOK (pH 5.5) containing 0.10 M NaCl or KCl. The FNDs with the highest binding affinities for tetraplex DNA showed 23- or 8-times higher preference for tetraplex DNA than for single- or double-stranded DNA, respectively. The current signals generated from the seven FNDs bound to the tetraplex DNA immobilized on the electrode were found to correlate with the binding affinities of these ligands for the tetraplex DNA. Furthermore, using the telomerase repeat amplification protocol assay, the FND ligands could be categorized into three groups: (a) inhibiting both telomerase and Taq polymerase, (b) inhibiting telomerase alone, and (c) inhibiting neither telomerase nor Taq polymerase.}, pages = {21--26}, title = {Ferrocenyl naphthalene diimides as tetraplex DNA binders}, volume = {167}, year = {2016}, yomi = {サトウ, シノブ and タケナカ, シゲオリ} }