{"created":"2023-05-15T11:59:36.592274+00:00","id":6107,"links":{},"metadata":{"_buckets":{"deposit":"414e59d0-6844-4b8a-84dc-bc53a9ce018b"},"_deposit":{"created_by":3,"id":"6107","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6107"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:00006107","sets":["8:24"]},"author_link":["6749","25112","25114","5963"],"item_21_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"335","bibliographicPageStart":"329","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters"}]}]},"item_21_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To identify an effective ligand that binds to a G-quadruplex structure but not a double-stranded DNA (dsDNA), a set of biophysical and biochemical experiments were carried out using newly synthesized cyclic ferrocenylnaphthalene diimide (cFNDI, 1) or the non-cyclic derivative (2) with various structures of G-quadruplex DNAs and dsDNA. Compound 1 bound strongly to G-quadruplexes DNAs (106 M−1 order) with diminished binding to dsDNA (104 M−1 order) in 100 mM AcOH-AcOK buffer (pH 5.5) containing 100 mM KCl. Interestingly, 1 showed an approximately 50-fold higher selectivity to mixed hybrid-type telomeric G-quadruplex DNA (K = 3.4 × 106 M−1 and a 2:1 stoichiometry) than dsDNA (K = 7.5 × 104 M−1) did. Furthermore, 1 showed higher thermal stability to G-quadruplex DNAs than it did to dsDNA with a preference for c-kit and c-myc G-quadruplex DNAs over telomeric and thrombin binding aptamers. Additionally, 1 exhibited telomerase inhibitory activity with a half-maximal inhibitory concentration (IC50) of 0.4 μM. Compound 2 showed a preference for G-quadruplex; however, the binding affinity magnitude and preference were improved in 1 because the former had a cyclic structure.","subitem_description_type":"Abstract"}]},"item_21_description_60":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_21_link_62":{"attribute_name":"研究者情報","attribute_value_mlt":[{"subitem_link_url":"https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html"}]},"item_21_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_21_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmcl.2016.11.037","subitem_relation_type_select":"DOI"}}]},"item_21_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2016 Elsevier Ltd."}]},"item_21_select_59":{"attribute_name":"査読の有無","attribute_value_mlt":[{"subitem_select_item":"yes"}]},"item_21_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"ISSN"}]},"item_21_subject_16":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"579","subitem_subject_scheme":"NDC"}]},"item_21_text_36":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"},{"subitem_text_value":"Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Center for Bio-microsensing Technology, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"},{"subitem_text_value":"Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"},{"subitem_text_value":"Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Center for Bio-microsensing Technology, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan"}]},"item_21_text_63":{"attribute_name":"連携ID","attribute_value_mlt":[{"subitem_text_value":"7831"}]},"item_21_version_type_58":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Islam,  Md. Monirul"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Sato, Shinobu","creatorNameLang":"en"},{"creatorName":"佐藤, しのぶ","creatorNameLang":"ja"},{"creatorName":"サトウ, シノブ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Shinozaki,  Shingo"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Takenaka, Shigeori","creatorNameLang":"en"},{"creatorName":"竹中, 繁織","creatorNameLang":"ja"},{"creatorName":"タケナカ, シゲオリ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"j.bmcl.2016.11.037.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"j.bmcl.2016.11.037.pdf","url":"https://kyutech.repo.nii.ac.jp/record/6107/files/j.bmcl.2016.11.037.pdf"},"version_id":"2186fe9c-1da2-4d1e-a6ff-29098ca197ae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cyclic ferrocenylnaphthalene diimide","subitem_subject_scheme":"Other"},{"subitem_subject":"Tetraplex DNA binder","subitem_subject_scheme":"Other"},{"subitem_subject":"G-quadruplex DNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Human telomere DNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Promotor region","subitem_subject_scheme":"Other"},{"subitem_subject":"Thrombin binding aptamer","subitem_subject_scheme":"Other"},{"subitem_subject":"Double stranded DNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand"}]},"item_type_id":"21","owner":"3","path":["24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-08-19"},"publish_date":"2019-08-19","publish_status":"0","recid":"6107","relation_version_is_last":true,"title":["Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-10-25T07:51:43.821278+00:00"}