{"created":"2023-05-15T11:59:40.348638+00:00","id":6204,"links":{},"metadata":{"_buckets":{"deposit":"823c68a9-1e7a-4723-8c27-59027b70b8ad"},"_deposit":{"created_by":3,"id":"6204","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6204"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:00006204","sets":["8:24"]},"author_link":["6749","25541","5963","25544","25543"],"item_21_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"24","bibliographicPageEnd":"6411","bibliographicPageStart":"6404","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry"}]}]},"item_21_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Synthesized cyclic perylene diimide, cPDI, showed the binding constant of 6.3 × 106 M−1 with binding number of n = 2 with TA-core as a tetraplex DNA in 50 mM Tris-HCl buffer (pH = 7.4) containing 100 mM KCl using Schatchard analysis and showed a higher preference for tetraplex DNA than for double stranded DNA with over 103 times. CD spectra showed that TA-core induced its antiparallel conformation upon addition of cPDI in the absence or presence of K+ or Na+ ions. The cPDI inhibits the telomerase activity with IC50 of 0.3 µM using TRAP assay which is potential anti-cancer drug with low side effect.","subitem_description_type":"Abstract"}]},"item_21_description_60":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_21_link_62":{"attribute_name":"研究者情報","attribute_value_mlt":[{"subitem_link_url":"https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html"}]},"item_21_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_21_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmc.2017.10.014","subitem_relation_type_select":"DOI"}}]},"item_21_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2017 Elsevier Ltd. All rights reserved."}]},"item_21_select_59":{"attribute_name":"査読の有無","attribute_value_mlt":[{"subitem_select_item":"yes"}]},"item_21_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0968-0896","subitem_source_identifier_type":"ISSN"}]},"item_21_subject_16":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"579","subitem_subject_scheme":"NDC"}]},"item_21_text_36":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Research Center for Biomicrosensing Technology, Kyushu Institute of Technology, Kitakyushu, Fukuoka 804-8550, Japan"},{"subitem_text_value":"Research Center for Biomicrosensing Technology, Kyushu Institute of Technology, Kitakyushu, Fukuoka 804-8550, Japan, Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu, Fukuoka 804-8550, Japan"},{"subitem_text_value":"Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu, Fukuoka 804-8550, Japan"},{"subitem_text_value":"Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu, Fukuoka 804-8550, Japan"},{"subitem_text_value":"Research Center for Biomicrosensing Technology, Kyushu Institute of Technology, Kitakyushu, Fukuoka 804-8550, Japan, Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu, Fukuoka 804-8550, Japan"}]},"item_21_text_63":{"attribute_name":"連携ID","attribute_value_mlt":[{"subitem_text_value":"7833"}]},"item_21_version_type_58":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Vasimalla,  Suresh"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Sato, Shinobu","creatorNameLang":"en"},{"creatorName":"佐藤, しのぶ","creatorNameLang":"ja"},{"creatorName":"サトウ, シノブ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Takenaka,  Fuminori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurose,  Yui"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Takenaka, Shigeori","creatorNameLang":"en"},{"creatorName":"竹中, 繁織","creatorNameLang":"ja"},{"creatorName":"タケナカ, シゲオリ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-21"}],"displaytype":"detail","filename":"j.bmc.2017.10.014.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"j.bmc.2017.10.014.pdf","url":"https://kyutech.repo.nii.ac.jp/record/6204/files/j.bmc.2017.10.014.pdf"},"version_id":"091a3db8-fcd2-4d77-b1bc-e38d382e0da3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cyclic perylene diimide","subitem_subject_scheme":"Other"},{"subitem_subject":"Tetraplex specific ligand","subitem_subject_scheme":"Other"},{"subitem_subject":"Human telomere DNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Antiparallel tetraplex DNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Inhibition of telomerase activity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA"}]},"item_type_id":"21","owner":"3","path":["24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-21"},"publish_date":"2019-10-21","publish_status":"0","recid":"6204","relation_version_is_last":true,"title":["Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-10-25T07:51:44.269790+00:00"}