{"created":"2023-05-15T11:59:48.507408+00:00","id":6408,"links":{},"metadata":{"_buckets":{"deposit":"d6a19797-d47f-49d3-a3e8-4ed0b86e86ce"},"_deposit":{"created_by":3,"id":"6408","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6408"},"status":"published"},"_oai":{"id":"oai:kyutech.repo.nii.ac.jp:00006408","sets":["8:9"]},"author_link":["26835","6749","26832","5963"],"control_number":"6408","item_21_alternative_title_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Signal-on Type Electrochemical Detection of DNase I in Homogeneous Media Using New Ferrocenylnaphthalene Diimide","subitem_alternative_title_language":"en"}]},"item_21_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"960","bibliographicPageStart":"953","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"分析化学"}]}]},"item_21_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A simple DNase I detecting method was achieved under a homogenous medium containing DNA duplex and a newly synthesized ferrocenylnaphthalene diimide derivative (FND) carrying alanine (1) or alanine-lysine residue (2) as an electrochemical indicator. The binding affinity of 1 or 2 with double stranded DNA was 105 M−1 or 106 M−1 order, which was estimated from a Scatchard analysis calculated by its absorption change upon the addition of calf thymus DNA (CT-DNA). It was expected that 1 or 2 intercalated to double stranded DNA with a threading mode and electrostatic interaction of the linker ammonium cations of 1 or 2 with phosphate anions of the DNA duplex backbone. The largest current increase after a DNase I treatment was observed under the mixture in a ratio of [3]:[CT-DNA-bp] = 10 : 1 (bp: DNA concentration per base pair), where the distance between the bound ligands is expected to a 10 bp or 34 Å theoretically. When considering to be ca. 30 Å of DNase I size and decreasing of the current increase under an increased amount of 3, DNase I required over ten base pairs to access and digest with the DNA duplex. The current increase in the case of a mixture of 10 μM 1 or 2 and 100 μM CT-DNA was obtained 340 % or 640 %, respectively, after being treated with DNase I (final concentration: 2.0 × 10−3 U μL−1), which might be derived from an apperarent molecular weight or diffusion coefficient of the ligand bound DNA duplex and the detection limit of DNase I in the case of 1 or 2 was 2.0 × 10−5 or 2.0 × 10−9 U μL−1, respectively, where the detection limit for 2 was 104-times higher than that for 1.","subitem_description_type":"Abstract"}]},"item_21_description_60":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal 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(c) 2019 The Japan Society for Analytical Chemistry"}]},"item_21_select_59":{"attribute_name":"査読の有無","attribute_value_mlt":[{"subitem_select_item":"yes"}]},"item_21_source_id_10":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00222633","subitem_source_identifier_type":"NCID"}]},"item_21_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0525-1931","subitem_source_identifier_type":"PISSN"}]},"item_21_text_36":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"九州工業大学大学院工学研究院物質工学研究系 804-8550福岡県北九州市戸畑区仙水町1-1, 九州工業大学バイオマイクロセンシング技術研究センター"},{"subitem_text_value":"九州工業大学大学院工学研究院物質工学研究系 804-8550福岡県北九州市戸畑区仙水町1-1"},{"subitem_text_value":"九州工業大学大学院工学研究院物質工学研究系 804-8550福岡県北九州市戸畑区仙水町1-1, 九州工業大学バイオマイクロセンシング技術研究センター"}]},"item_21_text_63":{"attribute_name":"連携ID","attribute_value_mlt":[{"subitem_text_value":"8125"}]},"item_21_version_type_58":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Sato, Shinobu","creatorNameLang":"en"},{"creatorName":"佐藤, しのぶ","creatorNameLang":"ja"},{"creatorName":"サトウ, シノブ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"福瀧,  修司","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Takenaka, 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detection","subitem_subject_scheme":"Other"},{"subitem_subject":"ferrocenylnaphthalene diimide","subitem_subject_scheme":"Other"},{"subitem_subject":"homogenous medium","subitem_subject_scheme":"Other"},{"subitem_subject":"signal-on type detection","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規フェロセン化ナフタレンジイミドを用いる均一溶液中でのシグナルオン型電気化学的DNase I検出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規フェロセン化ナフタレンジイミドを用いる均一溶液中でのシグナルオン型電気化学的DNase I検出","subitem_title_language":"ja"}]},"item_type_id":"21","owner":"3","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-02-17"},"publish_date":"2020-02-17","publish_status":"0","recid":"6408","relation_version_is_last":true,"title":["新規フェロセン化ナフタレンジイミドを用いる均一溶液中でのシグナルオン型電気化学的DNase I検出"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-02T08:41:09.206833+00:00"}