@article{oai:kyutech.repo.nii.ac.jp:00006420,
 author = {Zou,  Tingting and Sato, Shinobu and 佐藤, しのぶ and Yasukawa,  Rui and Takeuchi,  Ryusuke and Ozaki,  Shunsuke and Fujii,  Satoshi and Takenaka, Shigeori and 竹中, 繁織},
 issue = {3},
 journal = {Molecules},
 month = {Feb},
 note = {G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation. However, G4 ligands recognizing G-quadruplex were generally investigated within a dilute condition, which might be interfered with under a cellular crowding environment. Here, we designed and synthesized several new cyclic naphthalene diimide (cNDI) derivatives, and investigated their interaction with G-quadruplex under molecular crowding condition (40% v/v polyethylene glycol (PEG)200) to mimic the cellular condition. The results indicated that, under molecular crowding conditions, cNDI derivatives were still able to recognize and stabilize G-quadruplex structures based on circular dichroism measurement. The binding affinities were slightly decreased but still comparatively high upon determination by isothermal titration calorimetry and UV-vis absorbance spectroscopy. More interestingly, cNDI derivatives were observed with preference to induce a telomere sequence to form a hybrid G-quadruplex under cation-deficient molecular crowding conditions},
 pages = {668-1--668-10},
 title = {The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition},
 volume = {25},
 year = {2020},
 yomi = {サトウ, シノブ and タケナカ, シゲオリ}
}