@article{oai:kyutech.repo.nii.ac.jp:00007187, author = {Sato, Shinobu and 佐藤, しのぶ and Kajima, Atsuhito and Hamanaka, Hisashi and Takenaka, Shigeori and 竹中, 繁織}, journal = {Journal of Organometallic Chemistry}, month = {Jun}, note = {Naphthalene diimide carrying four ferrocenyl substituents, tFND1 and tFND2, were newly synthesized to expect the improved binding affinity for tetraplex DNA and specific electrochemical signal generation. tFND2 shows the 1:2 binding to tetraplex A-core DNA, which has a part of human telomere sequence based on circular dichroism spectra, and the current increase of tFND2 on the tetraplex DNA-immobilized electrode was 13.5-times higher than that on the single stranded DNA-immobilized electrode. When applied to an electrochemical telomerase assay (ECTA) for HeLa cell, tFND2 shows the quantitative change around 0.1–50 cells/μL and the detection limit of 0.1 cells/μL for HeLa cell.}, pages = {107--113}, title = {Naphthalene diimide carrying four ferrocenyl substitutes as an electrochemical indicator of tetraplex DNA aiming at cancer diagnosis}, volume = {897}, year = {2019}, yomi = {サトウ, シノブ and タケナカ, シゲオリ} }