WEKO3
アイテム
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Electrochemical Aberrant Methylation Detection Based on Ferrocenyl Naphthalene Diimide Carrying β-cyclodextrin, FNC
http://hdl.handle.net/10228/00008217
http://hdl.handle.net/10228/000082171983aec8-80e4-4469-9b05-114a8508aff3
名前 / ファイル | ライセンス | アクション |
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10344701.pdf (363.4 kB)
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Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||
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公開日 | 2021-04-22 | |||||||||||||||||
資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | journal article | |||||||||||||||||
タイトル | ||||||||||||||||||
タイトル | Electrochemical Aberrant Methylation Detection Based on Ferrocenyl Naphthalene Diimide Carrying β-cyclodextrin, FNC | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
著者 |
佐藤, しのぶ
× 佐藤, しのぶ
WEKO
5963
× Nishi, Yukiko× 竹中, 繁織
WEKO
6749
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抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | Electrochemical detection of the specific gene carrying aberrant methylated cytosine was achieved by ferrocenyl naphthalene diimide carrying β‐cyclodextrin (β‐CD), FNC, coupled with the probe‐DNA‐immobilized electrode. The five CpG sites in a 24‐base sequence were selected as the target DNA on the CDH4 gene, which is associated with colorectal cancer. When methylated and unmethylated samples hybridized with the DNA probe (HS‐M24) immobilized on the electrode, an increased current signal was observed in the electrolyte containing FNC and correlated with the amount of target DNA. Furthermore, an increase in current (115 %) was observed when the PCR product of 105 bp was hybridized on the HS‐M24‐immobilized electrode, whereas a background level of current increase was observed in the case of unmethylated product. Such large discrimination ability might be due to the inter‐ and/or intra‐complex formation of ferrocene with β‐CD of FNC on the surface of the electrode. | |||||||||||||||||
書誌情報 |
Electroanalysis 巻 31, 号 10, p. 1988-1993, 発行日 2019-01-01 |
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出版社 | ||||||||||||||||||
出版者 | Wiley‐VCH Verlag GmbH & Co. KGaA | |||||||||||||||||
DOI | ||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | https://doi.org/10.1002/elan.201900282 | |||||||||||||||||
日本十進分類法 | ||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||
主題 | 464 | |||||||||||||||||
ISSN | ||||||||||||||||||
収録物識別子タイプ | ISSN | |||||||||||||||||
収録物識別子 | 1521-4109 | |||||||||||||||||
著作権関連情報 | ||||||||||||||||||
権利情報 | Copyright (c) 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | aberrant methylation | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | cyclodextrin | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | electrochemical hybridization assay | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | ferrocene | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | naphthalene diimide derivative | |||||||||||||||||
出版タイプ | ||||||||||||||||||
出版タイプ | AM | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
査読の有無 | ||||||||||||||||||
値 | yes | |||||||||||||||||
研究者情報 | ||||||||||||||||||
https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html | ||||||||||||||||||
論文ID(連携) | ||||||||||||||||||
10344701 | ||||||||||||||||||
連携ID | ||||||||||||||||||
8735 | ||||||||||||||||||
著者別名 | ||||||||||||||||||
姓名 | Sato, Shinobu | |||||||||||||||||
言語 | en | |||||||||||||||||
姓名 | 佐藤, しのぶ | |||||||||||||||||
言語 | ja | |||||||||||||||||
姓名 | サトウ, シノブ | |||||||||||||||||
言語 | ja-Kana | |||||||||||||||||
著者別名 | ||||||||||||||||||
姓名 | Nishi, Y. | |||||||||||||||||
著者別名 | ||||||||||||||||||
姓名 | Takenaka, Shigeori | |||||||||||||||||
言語 | en | |||||||||||||||||
姓名 | 竹中, 繁織 | |||||||||||||||||
言語 | ja | |||||||||||||||||
姓名 | タケナカ, シゲオリ | |||||||||||||||||
言語 | ja-Kana |