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Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA
http://hdl.handle.net/10228/00007414
http://hdl.handle.net/10228/000074143e3dbe45-1737-48bf-95e5-3ce422877250
名前 / ファイル | ライセンス | アクション |
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j.bmc.2017.10.014.pdf (1.7 MB)
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Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||
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公開日 | 2019-10-21 | |||||||||||||||||
資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | journal article | |||||||||||||||||
タイトル | ||||||||||||||||||
タイトル | Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
著者 |
Vasimalla, Suresh
× Vasimalla, Suresh× 佐藤, しのぶ
WEKO
5963
× Takenaka, Fuminori× Kurose, Yui× 竹中, 繁織
WEKO
6749
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抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | Synthesized cyclic perylene diimide, cPDI, showed the binding constant of 6.3 × 106 M−1 with binding number of n = 2 with TA-core as a tetraplex DNA in 50 mM Tris-HCl buffer (pH = 7.4) containing 100 mM KCl using Schatchard analysis and showed a higher preference for tetraplex DNA than for double stranded DNA with over 103 times. CD spectra showed that TA-core induced its antiparallel conformation upon addition of cPDI in the absence or presence of K+ or Na+ ions. The cPDI inhibits the telomerase activity with IC50 of 0.3 µM using TRAP assay which is potential anti-cancer drug with low side effect. | |||||||||||||||||
書誌情報 |
Bioorganic & Medicinal Chemistry 巻 25, 号 24, p. 6404-6411, 発行日 2017-10-21 |
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出版社 | ||||||||||||||||||
出版者 | Elsevier | |||||||||||||||||
DOI | ||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | https://doi.org/10.1016/j.bmc.2017.10.014 | |||||||||||||||||
日本十進分類法 | ||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||
主題 | 579 | |||||||||||||||||
ISSN | ||||||||||||||||||
収録物識別子タイプ | ISSN | |||||||||||||||||
収録物識別子 | 0968-0896 | |||||||||||||||||
著作権関連情報 | ||||||||||||||||||
権利情報 | Copyright (c) 2017 Elsevier Ltd. All rights reserved. | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Cyclic perylene diimide | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Tetraplex specific ligand | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Human telomere DNA | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Antiparallel tetraplex DNA | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Inhibition of telomerase activity | |||||||||||||||||
出版タイプ | ||||||||||||||||||
出版タイプ | AM | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
査読の有無 | ||||||||||||||||||
値 | yes | |||||||||||||||||
研究者情報 | ||||||||||||||||||
https://hyokadb02.jimu.kyutech.ac.jp/html/97_ja.html | ||||||||||||||||||
連携ID | ||||||||||||||||||
7833 |