| アイテムタイプ |
学術雑誌論文 = Journal Article(1) |
| 公開日 |
2024-06-12 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| タイトル |
|
|
タイトル |
Behavioral Forgetting of Olfactory Learning Is Mediated by Interneuron-Regulated Network Plasticity in Caenorhabditis elegans |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 著者 |
Teo, Jamine Hooi-Min
Kurokawa, Itsuki
Onishi, Yuuki
Sato, Noriko
Kitazono, Tomohiro
徳永, 旭将
Fujiwara, Manabi
Ishihara, Takeshi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Forgetting is important for animals to manage acquired memories to enable adaptation to changing environments; however, the neural network in mechanisms of forgetting is not fully understood. To understand the mechanisms underlying forgetting, we examined olfactory adaptation, a form of associative learning, in Caenorhabditis elegans. The forgetting of diacetyl olfactory adaptation in C. elegans is regulated by secreted signals from AWC sensory neurons via the TIR-1/JNK-1 pathway. These signals cause a decline of the sensory memory trace in AWA neurons, where diacetyl is mainly sensed. To further understand the neural network that regulates this forgetting, we investigated the function of interneurons downstream of AWA and AWC neurons. We found that a pair of interneurons, AIA, is indispensable for the proper regulation of behavioral forgetting of diacetyl olfactory adaptation. Loss or inactivation of AIA caused the impairment of the chemotaxis recovery after adaptation without causing severe chemotaxis defects in the naive animal. AWA Ca2+ imaging analyses suggested that loss or inactivation of AIA interneurons did not affect the decline of the sensory memory trace after the recovery. Furthermore, AIA responses to diacetyl were observed in naive animals and after the recovery, but not just after the conditioning, suggesting that AIA responses after the recovery are required for the chemotaxis to diacetyl. We propose that the functional neuronal circuit for attractive chemotaxis to diacetyl is changed temporally at the recovery phase so that AIA interneurons are required for chemotaxis, although AIAs are dispensable for attractive chemotaxis to diacetyl in naive animals. |
|
言語 |
en |
| 書誌情報 |
en : eNeuro
巻 9,
号 4,
p. 0084-22,
発行日 2022-08-17
|
| 出版社 |
|
|
出版者 |
Society for Neuroscience |
|
言語 |
en |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1523/ENEURO.0084-22.2022 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2373-2822 |
| 著作権関連情報 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
C. elegans |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
circuit plasticity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
forgetting |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
memory |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
olfactory learning |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読の有無 |
|
|
値 |
yes |
| 研究者情報 |
|
|
URL |
https://hyokadb02.jimu.kyutech.ac.jp/html/100000804_ja.html |
| 論文ID（連携） |
|
|
値 |
10435815 |
| 連携ID |
|
|
値 |
12357 |
10435815.pdf (1.7 MB)
