WEKO3
アイテム
Bioactive polymethylmethacrylate bone cement modified with combinations of phosphate group-containing monomers and calcium acetate
http://hdl.handle.net/10228/5536
http://hdl.handle.net/10228/5536c6082ff4-393d-4b19-8998-546d756f43ca
| 名前 / ファイル | ライセンス | アクション |
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JBA_29_1296.pdf (712.9 kB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2016-01-05 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Bioactive polymethylmethacrylate bone cement modified with combinations of phosphate group-containing monomers and calcium acetate | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| その他のタイトル | ||||||||||||||||||||||
| その他のタイトル | Bioactive PMMA bone cement modified with combinations of phosphate group-containing monomers and calcium acetate | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 著者 |
Liu, Jinkun
× Liu, Jinkun× 城崎, 由紀
WEKO
15664
× 宮崎, 敏樹
WEKO
6369
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Bone cement from polymethylmethacrylate powder and methylmethacrylate liquid has been successfully demonstrated as artificial material to anchor joint replacements in bone. However, it lacks the capability to bond directly to bone, so long-term implantation leads to an increased risk of loosening. Bioactive materials show better performance in fixation to bone, and the chemical bonding depends on bone-like apatite formation. This is triggered by surface reactions with body fluid. For these reactions, superficial functional groups like silanol (Si–OH) are ideal sites to induce apatite nucleation and the release of Ca2+ ions accelerates the apatite growth. Therefore, incorporation of materials containing these key components may provide the cement with apatite-forming ability. In this study, phosphoric acid 2-hydroxyethyl methacrylate ester or bis[2-(methacryloyloxy)ethyl] phosphate supplying a phosphate group (PO4H2) was added into methylmethacrylate liquid, while calcium acetate as a source of Ca2+ ions was mixed into polymethylmethacrylate powder. The influences of the combinations on the setting time and compressive strength were also investigated. Apatite was formed on the cements modified with 30 mass% of phosphoric acid 2-hydroxyethyl methacrylate ester or bis[2-(methacryloyloxy)ethyl] phosphate. The induction period was shortened with increased amounts of Ca(CH3COO)2. The setting time could be controlled by the Ca(CH3COO)2/monomer mass ratio. Faster setting was achieved at a ratio close to the mixing ratio of the powder/liquid (2:1), and both increases and decreases in the amount of Ca(CH3COO)2 prolonged the setting time based on this ratio. The highest compressive strength was 88.8 ± 2.6 MPa, higher than the lowest limit of ISO 5833 but was lower than that of the simulated body fluid-soaked reference. The increase of additives caused the decline in compressive strength. In view of balancing apatite formation and clinical standard, bis[2-(methacryloyloxy)ethyl] phosphate is more suitable as an additive, and the optimal modification is a combination of 30 mass% of bis[2-(methacryloyloxy)ethyl] phosphate and 20 mass% of Ca(CH3COO)2. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : Journal of Biomaterials Applications 巻 29, 号 9, p. 1296-1303, 発行日 2015-04-01 |
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| 出版社 | ||||||||||||||||||||||
| 出版者 | Sage Publications | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1177/0885328214562436 | |||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 0885-3282 | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 1530-8022 | |||||||||||||||||||||
| 著作権関連情報 | ||||||||||||||||||||||
| 権利情報 | Sage Publications | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Bioactive PMMA bone cement | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Phosphate group-containing monomers | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Calcium acetate | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Compressive strength | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Simulated body fluid (SBF) | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
| 査読の有無 | ||||||||||||||||||||||
| 値 | yes | |||||||||||||||||||||
| 研究者情報 | ||||||||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||||||||||
| 連携ID | ||||||||||||||||||||||
| 値 | 5262 | |||||||||||||||||||||
