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Yttrium phosphate microspheres with enriched phosphorus content prepared for radiotherapy of deep-seated cancer
http://hdl.handle.net/10228/5926
http://hdl.handle.net/10228/59268c6b9f8e-7564-41e4-94e5-3f38c06f072f
| 名前 / ファイル | ライセンス | アクション |
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CI40_15259.pdf (384.8 kB)
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| Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2016-12-02 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Yttrium phosphate microspheres with enriched phosphorus content prepared for radiotherapy of deep-seated cancer | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 著者 |
宮崎, 敏樹
× 宮崎, 敏樹
WEKO
6369
× Tanaka, Toru× 城崎, 由紀
WEKO
15664
× Kawashita, Masakazu |
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Ceramic microspheres composed of β-emitters are useful for in situ radiotherapy of deep-seated cancer by implantation around the tumor. In addition, microspheres 20–30 µm in diameter can combine β-emission with the embolization effect. Yttrium phosphate is an attractive candidate material for such microspheres, because both Y and P play roles as β-emitters. The half-life of 31P is known to be much larger than that of 90Y. Therefore, it is expected that yttrium phosphate microspheres with high P content can maintain a longer radiotherapy effect. In the present study, preparation of microspheres with enriched P content has been attempted by water-in-oil emulsions using polyphosphate as a starting material. Yttrium phosphate microspheres with a higher P/Y molar ratio (2.5) than in previously reported YPO4 microspheres were obtained. It was found that emulsification for sufficient time (more than 10 min) is necessary to obtain microspheres that are 20–30 µm in size. Although the microspheres released Y sparingly, they released larger amounts of P than previously reported YPO4 microspheres in a simulated body environment. Heat treatment at moderate temperature can suppress P release to some extent. Further improvement in chemical durability through surface modification is essential for long-term clinical use. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : Ceramics International 巻 40, 号 9, p. 15259-15263, 発行日 2014-07-09 |
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| 出版社 | ||||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.ceramint.2014.07.018 | |||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA10622625 | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 0272-8842 | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 1873-3956 | |||||||||||||||||||||
| 著作権関連情報 | ||||||||||||||||||||||
| 権利情報 | Copyright (c) 2014 Elsevier Ltd and Techna Group S.r.l. | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | A. Powders | |||||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | chemical preparation | |||||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | C. Chemical properties | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | E. Biomedical applications | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Yttrium phosphate | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
| 査読の有無 | ||||||||||||||||||||||
| 値 | yes | |||||||||||||||||||||
| 研究者情報 | ||||||||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||||||||||
| 連携ID | ||||||||||||||||||||||
| 値 | 5846 | |||||||||||||||||||||
