WEKO3
アイテム
Fabrication of Yttrium Phosphate Microcapsules by an Emulsion Route for in situ Cancer Radiotherapy
http://hdl.handle.net/10228/5933
http://hdl.handle.net/10228/593337a94919-d981-4d10-9e37-569b408938ff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JMBE34_14.pdf (295.5 kB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2016-12-02 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Fabrication of Yttrium Phosphate Microcapsules by an Emulsion Route for in situ Cancer Radiotherapy | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 著者 |
宮崎, 敏樹
× 宮崎, 敏樹
WEKO
6369
× Suda, Takajin× 城崎, 由紀
WEKO
15664
× Kawashita, Masakazu |
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Radiotherapy is a novel, non-invasive cancer treatment. Radioactive hollow microspheres, i.e., microcapsules, are attractive for in situ cancer radiotherapy because they can effectively reach tumors without settling in blood vessels. In particular, microcapsules 20-30 µm in size are expected to exhibit not only a radiotherapy effect but also embolization that blocks the nutrient supply to cancer cells. β-ray irradiation is the most suitable source for in situ radiotherapy because of its moderate range. Several kinds of β-emitting yttria (Y2O3) microcapsules have therefore been developed. Yttrium phosphate (YPO4) should have a longer irradiation effect than that of Y2O3 because the half-life of 31P (14.3days) is longer than that of 90Y (64.1 hours). However, the preparation of YPO4 microcapsules has not been reported to date. In the present study, YPO4 microcapsules were fabricated using a water/oil (W/O) emulsion prepared by first dispersing a YPO4 sol into toluene containing a surfactant, with mechanical homogenization. The emulsion was then added into butanol to dehydrate the water phase and precipitate microcapsules. These were then heat-treated to improve their mechanical strength and chemical stability. Microcapsule fragility at low YPO4 sol concentrations in the water phase was attributed to the thinness of the microcapsule shell. The size of the microcapsules decreased with increasing emulsification speed. The chemical stability of the prepared microcapsules is similar to those of previously reported YPO4 and Y2O3 microspheres in weakly acidic conditions. Thus, little leakage of radioactive species into nearby healthy tissues is expected. The obtained microcapsules are expected to be highly effective for cancer radiotherapy. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : Journal of Medical and Biological Engineering 巻 34, p. 14-17, 発行日 2014-02 |
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| 出版社 | ||||||||||||||||||||||
| 出版者 | JMBE | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.5405/jmbe.1451 | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 1609-0985 | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2199-4757 | |||||||||||||||||||||
| 著作権関連情報 | ||||||||||||||||||||||
| 権利情報 | JMBE | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Yttrium phosphate | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Microcapsule | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Cancer treatment | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Radiotherapy | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Emulsion | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Chemical durability | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| 査読の有無 | ||||||||||||||||||||||
| 値 | yes | |||||||||||||||||||||
| 研究者情報 | ||||||||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||||||||||
| 連携ID | ||||||||||||||||||||||
| 値 | 5858 | |||||||||||||||||||||
