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Structural effects of phosphate groups on apatite formation in a copolymer modified with Ca2+ in a simulated body fluid
http://hdl.handle.net/10228/00007042
http://hdl.handle.net/10228/00007042c39ee1d3-684f-422c-b022-7e739ae047ff
| 名前 / ファイル | ライセンス | アクション |
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JMCB6_174.pdf (2.0 MB)
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| Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||
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| 公開日 | 2019-02-19 | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Structural effects of phosphate groups on apatite formation in a copolymer modified with Ca2+ in a simulated body fluid | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
| 著者 |
Ryo, Hamai
× Ryo, Hamai× Hirotaka, Maeda× Hikaru, Sawai× 城崎, 由紀
WEKO
15664
× Toshihiro, Kasuga× 宮崎, 敏樹
WEKO
6369
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Organic–inorganic composites are novel bone substitutes that can ameliorate the mismatch of Young's moduli between natural bone and implanted ceramics. Phosphate groups contribute to the formation of apatite in a simulated body fluid (SBF) and the adhesion of osteoblast-like cells. Therefore, modification of a polymer with these functional groups is expected to enhance the ability of the organic–inorganic composite to bond with bone. Two phosphate groups have been used, phosphonic acid (–C–PO3H2) and phosphoric acid (–O–PO3H2). However, the effects of structural differences between these phosphate groups have not been clarified. In this study, the apatite formation of copolymers modified with Ca2+ and either –C–PO3H2 or –O–PO3H2 was examined. The mechanism of apatite formation is discussed based on analytical and computational approaches. The copolymers containing –O–PO3H2, but not those containing –C–PO3H2, formed apatite in the SBF, although both released similar amounts of Ca2+ into the SBF. Adsorption of HPO42− from –O–PO3H2 in the SBF following Ca2+ adsorption was confirmed by zeta-potential measurement and X-ray photoelectron spectroscopy. The measurement of the complex formation constant revealed that the –O–PO32−⋯Ca2+ complex was thermodynamically unstable enough to convert into CaHPO4, which was not the case with –C–PO32−⋯Ca2+. The formation of CaHPO4-based clusters was found to be a key factor for apatite nucleation. In conclusion, this study revealed that modification with –O–PO3H2 was more effective for enhancing apatite formation compared with –C–PO3H2. | |||||||||||||||||
| 書誌情報 |
en : Journal of Materials Chemistry B 巻 6, 号 1, p. 174-182, 発行日 2018-01-07 |
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| 出版者 | Royal Society of Chemistry | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1039/C7TB02363D | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12605004 | |||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 2050-750X | |||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||
| 収録物識別子 | 2050-7518 | |||||||||||||||||
| 著作権関連情報 | ||||||||||||||||||
| 権利情報 | Copyright (c) The Royal Society of Chemistry 2018 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
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| 値 | yes | |||||||||||||||||
| 研究者情報 | ||||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||||||
| 論文ID（連携） | ||||||||||||||||||
| 値 | 10309734 | |||||||||||||||||
| 連携ID | ||||||||||||||||||
| 値 | 6474 | |||||||||||||||||
