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In vitro apatite formation and drug loading/release of porous TiO2 microspheres prepared by sol-gel processing with different SiO2 nanoparticle contents
http://hdl.handle.net/10228/6039
http://hdl.handle.net/10228/603971771d89-886e-4da1-b056-66e7661a57cd
名前 / ファイル | ライセンス | アクション |
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MSEC50_317.pdf (1.3 MB)
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Item type | 学術雑誌論文 = Journal Article(1) | |||||||||||
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公開日 | 2017-02-17 | |||||||||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
タイトル | ||||||||||||
タイトル | In vitro apatite formation and drug loading/release of porous TiO2 microspheres prepared by sol-gel processing with different SiO2 nanoparticle contents | |||||||||||
言語 | en | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
著者 |
Kawashita, Masakazu
× Kawashita, Masakazu× Tanaka, Yui× Ueno, Shoji× Liu, Gengci× Li, Zhixia× 宮崎, 敏樹
WEKO
6369
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内容記述タイプ | Abstract | |||||||||||
内容記述 | Bioactive titania (TiO2) microparticles can be used as drug-releasing cement fillers for the chemotherapeutic treatment of metastatic bone tumors. Porous anatase-type TiO2 microspheres around 15 μm in diameter were obtained through a sol–gel process involving a water-in-oil emulsion with 30:70 SiO2/H2O weight ratio and subsequent NaOH solution treatment. The water phase consisted of methanol, titanium tetraisopropoxide, diethanolamine, SiO2 nanoparticles, and H2O, while the oil phase consisted of kerosene, Span 80, and Span 60. The resulting microspheres had a high specific surface area of 111.7 m2·g− 1. Apatite with a network-like surface structure formed on the surface of the microspheres within 8 days in simulated body fluid. The good apatite-forming ability of the microspheres is attributed to their porous structure and the negative zeta potential of TiO2. The release of rhodamine B, a model for a hydrophilic drug, was rapid for the first 6 h of soaking, but diffusion-controlled thereafter. The burst release in the first 6 h is problematic for clinical applications; nonetheless, the present results highlight the potential of porous TiO2 microspheres as drug-releasing cement fillers able to form apatite. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
en : Materials Science and Engineering: C 巻 50, p. 317-323, 発行日 2015-02-17 |
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出版者 | Elsevier | |||||||||||
DOI | ||||||||||||
関連タイプ | isVersionOf | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | https://doi.org/10.1016/j.msec.2015.02.017 | |||||||||||
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収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA11537849 | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 0928-4931 | |||||||||||
著作権関連情報 | ||||||||||||
権利情報 | Copyright (c) 2015 Elsevier B.V. | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | TiO2; Microsphere | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Apatite | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Rhodamine B | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Bioactivity | |||||||||||
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主題Scheme | Other | |||||||||||
主題 | Drug-release | |||||||||||
出版タイプ | ||||||||||||
出版タイプ | AM | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
査読の有無 | ||||||||||||
値 | yes | |||||||||||
研究者情報 | ||||||||||||
表示名 | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||
URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||
連携ID | ||||||||||||
値 | 5848 |