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The Conformation of de Novo Designed Amphiphilic Peptides with Six or Nine L-2-(2,2,2-Trifluoroethyl)glycines as the Hydrophobic Amino Acid
http://hdl.handle.net/10228/00006509
http://hdl.handle.net/10228/000065094af76d02-0ed4-4e59-93c7-69529365c051
| 名前 / ファイル | ライセンス | アクション |
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BCSJ73_439.pdf (2.8 MB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||
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| 公開日 | 2018-01-19 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| タイトル | ||||||
| タイトル | The Conformation of de Novo Designed Amphiphilic Peptides with Six or Nine L-2-(2,2,2-Trifluoroethyl)glycines as the Hydrophobic Amino Acid | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 著者 |
Arai, Toru
× Arai, Toru× Imachi, Takashi× 加藤, 珠樹× 西野, 憲和 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Amphiphilic 21-peptides with six and nine L-2-(2,2,2-trifluoroethyl)glycines as the hydrophobic amino acids and lysine and glutamic acid as the hydrophilic amino acids were synthesized. The CD spectra showed that these peptides with L-2-(2,2,2-trifluoroethyl)glycines took a random conformation in H2O. On the contrary, similar amphiphilic 21-peptides with leucine as the hydrophobic amino acids took a helical conformation in H2O. The peptides with L-2-(2,2,2-trifluoroethyl)glycines took a helical conformation in H2O containing a > 20% volume of 2,2,2-trifluoroethanol. These facts suggested the hydrophobic nature of the L-trifluoroethylglycines. The peptide with six L-2-(2,2,2-trifluoroethyl)glycines took a helical structure in methanol, however it slowly changed into the β-structure within 24 h. Interestingly, the peptide with nine L-2-(2,2,2-trifluoroethyl)glycines formed a stable helix under the same conditions. The peptide with nine L-2-(2,2,2-trifluoroethyl)glycines preferred a helical structure, probably because the assembling of the Tfeg side chains was more effective in forming its helix rather than the β-structure. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Bulletin of the Chemical Society of Japan 巻 73, 号 2, p. 439-445, 発行日 2000-02-01 |
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| 出版社 | ||||||
| 出版者 | 日本化学会 | |||||
| 言語 | ja | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1246/bcsj.73.439 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00580132 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0009-2673 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1348-0634 | |||||
| 著作権関連情報 | ||||||
| 権利情報 | 公益社団法人日本化学会 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 査読の有無 | ||||||
| 値 | yes | |||||
| 研究者情報 | ||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/114_ja.html | |||||
| 論文ID（連携） | ||||||
| 値 | 10020558 | |||||
| 連携ID | ||||||
| 値 | 276 | |||||
