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アイテム
Structural Effects of Sulfur-Containing Functional Groups on Apatite Formation on Ca2+-Modified Copolymers in a Simulated Body Environment
http://hdl.handle.net/10228/00007140
http://hdl.handle.net/10228/0000714068208b15-81e3-4530-b82e-8dc16ba13946
| 名前 / ファイル | ライセンス | アクション |
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acsomega.8b00694.pdf (2.2 MB)
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| アイテムタイプ | 学術雑誌論文 = Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2019-05-27 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Structural Effects of Sulfur-Containing Functional Groups on Apatite Formation on Ca2+-Modified Copolymers in a Simulated Body Environment | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| その他のタイトル | ||||||||||||||||||||||
| その他のタイトル | Structural effects of sulfur-containing functional groups on apatite formation on Ca2+-modified copolymers in a simulated body environment | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
| 著者 |
Hamai, Ryo
× Hamai, Ryo× 城崎, 由紀
WEKO
15664
× 宮崎, 敏樹
WEKO
6369
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Chemical modification with specific functional groups has been the conventional method to develop bone-bonding bioactive organic–inorganic hybrids. These materials are attractive as bone substitutes because they are flexible and have a Young’s modulus similar to natural bone. Immobilization of sulfonic acid groups (−SO3H) onto the polymer chain is expected to produce such hybrids because these groups induce apatite formation in a simulated body fluid (SBF) and enhance the activity of osteoblast-like cells. Sulfinic acid groups (−SO2H), which are derivatives of −SO3H, can also induce apatite nucleation. However, the structural effects of such sulfur-containing functional groups on apatite formation have not been elucidated. In the present study, apatite formation on Ca2+-modified copolymers containing −SO2H or −SO3H was investigated in a simulated body environment. The copolymer containing Ca2+ and −SO3H promoted Ca2+ release into the SBF and formed apatite faster (1 day) than the copolymer containing Ca2+ and −SO2H (14 days). In contrast, when they were not modified with Ca2+, the copolymer containing only −SO2H deposited the apatite faster (7 days) than that containing only −SO3H (>7 days) in the solution with Ca2+ concentration 1.5 times that of SBF. The former adsorbed larger amounts of Ca2+ than the latter. The measured stability constant of the complex indicated that the interaction of −SO2–···Ca2+ was more stable than that of −SO3–···Ca2+. It was found that both the release and adsorption of Ca2+ governed by the stability played an important role in induction of the apatite formation and that the apatite-forming ability of sulfur-containing functional groups drastically changed by the coexistence of Ca2+. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : ACS Omega 巻 3, 号 5, p. 5627-5633, 発行日 2018-05-25 |
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| 出版社 | ||||||||||||||||||||||
| 出版者 | American Chemical Society | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1021/acsomega.8b00694 | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2470-1343 | |||||||||||||||||||||
| 著作権関連情報 | ||||||||||||||||||||||
| 権利情報 | American Chemical Society | |||||||||||||||||||||
| 著作権関連情報 | ||||||||||||||||||||||
| 権利情報 | This material is excerpted from a work that was published in ACS Omega, copyright © American Chemical Society after peer review. | |||||||||||||||||||||
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| 権利情報 | To access the final edited and published work see DOI: 10.1021/acsomega.8b00694. | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
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| 値 | yes | |||||||||||||||||||||
| 研究者情報 | ||||||||||||||||||||||
| URL | https://hyokadb02.jimu.kyutech.ac.jp/html/323_ja.html | |||||||||||||||||||||
| 論文ID（連携） | ||||||||||||||||||||||
| 値 | 10318550 | |||||||||||||||||||||
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| 値 | 7032 | |||||||||||||||||||||
